{"id":11769,"date":"2026-09-07T12:59:04","date_gmt":"2026-09-07T03:59:04","guid":{"rendered":"https:\/\/kojihifu.com\/english\/?p=11769"},"modified":"2026-09-07T12:59:05","modified_gmt":"2026-09-07T03:59:05","slug":"nmn-drip-therapy-tokyo-guide-2","status":"publish","type":"post","link":"https:\/\/kojihifu.com\/english\/nmn-drip-therapy-tokyo-guide-2\/","title":{"rendered":"NMN Drip Therapy Tokyo: Anti-Aging IV Treatment Guide"},"content":{"rendered":"<p><script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"MedicalWebPage\",\"@id\":\"https:\/\/kojihifu.com\/english\/nmn-drip-therapy-tokyo-guide\/#webpage\",\"url\":\"https:\/\/kojihifu.com\/english\/nmn-drip-therapy-tokyo-guide\/\",\"name\":\"NMN Drip Therapy Tokyo: Anti-Aging IV Treatment Guide\",\"inLanguage\":\"en\",\"isPartOf\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#website\"},\"about\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#clinic-biotope\"},\"reviewedBy\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#physician-karibe\"},\"lastReviewed\":\"2026-09-06\"},{\"@type\":[\"Article\",\"MedicalWebPage\"],\"@id\":\"https:\/\/kojihifu.com\/english\/nmn-drip-therapy-tokyo-guide\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/kojihifu.com\/english\/nmn-drip-therapy-tokyo-guide\/#webpage\"},\"headline\":\"NMN Drip Therapy Tokyo: Anti-Aging IV Treatment Guide\",\"url\":\"https:\/\/kojihifu.com\/english\/nmn-drip-therapy-tokyo-guide\/\",\"inLanguage\":\"en\",\"author\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#physician-karibe\"},\"reviewedBy\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#physician-karibe\"},\"publisher\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#organization\"},\"mainEntityOfPage\":{\"@id\":\"https:\/\/kojihifu.com\/english\/nmn-drip-therapy-tokyo-guide\/#webpage\"},\"description\":\"NMN drip therapy in Tokyo: an evidence-based anti-aging IV treatment guide covering NAD+ science, costs, and candidacy. Message our English-speaking team.\",\"datePublished\":\"2026-09-06\",\"dateModified\":\"2026-09-06\",\"lastReviewed\":\"2026-09-06\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/kojihifu.com\/english\/nmn-drip-therapy-tokyo-guide\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/kojihifu.com\/english\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Skin & Dermatology\",\"item\":\"https:\/\/kojihifu.com\/english\/column\/skin-dermatology\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"NMN Drip Therapy Tokyo: Anti-Aging IV Treatment Guide\",\"item\":\"https:\/\/kojihifu.com\/english\/nmn-drip-therapy-tokyo-guide\/\"}]}]}<\/script><br \/>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"How often should NMN drips be repeated?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Our clinic's published guidance suggests intervals of roughly one to four weeks for patients seeking sustained effects. The appropriate interval depends on your goals and response, and should be set at consultation rather than fixed in advance.\"}}, {\"@type\": \"Question\", \"name\": \"Will I feel a difference immediately?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Some patients report improved energy or sleep, but these are subjective impressions rather than trial endpoints, and no reputable clinic can promise a specific outcome. The one measurable, published short-term change after IV NMN is a rise in blood NAD+ within hours of infusion.\"}}, {\"@type\": \"Question\", \"name\": \"Is NMN drip therapy covered by Japanese health insurance?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"No. Because NMN is classified as a non-pharmaceutical ingredient in Japan, drips are entirely self-pay. You should budget for the full listed price, and note that National Health Insurance and most travel insurance will not reimburse elective anti-ageing treatment.\"}}, {\"@type\": \"Question\", \"name\": \"Can I do this as a visitor to Tokyo on a short trip?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Yes \u2014 the session takes about 15 to 30 minutes with no downtime, so a single infusion fits easily into a trip. Both clinics in our group provide English-language consultation, so you can discuss suitability before booking.\"}}]}<\/script><\/p>\n<h2>NMN Drip Therapy in Tokyo: An Evidence-Based Guide to Anti-Ageing IV Treatment<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"NMN drip therapy Tokyo: anti-aging IV treatment gu \u2014 NMN Drip Therapy in Tokyo: An Evidence-Based Guide to Anti-A\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_6129691_1788650440.webp\" alt=\"NMN drip therapy Tokyo: anti-aging IV treatment gu \u2014 NMN Drip Therapy in Tokyo: An Evidence-Based Guide to Anti-A\" \/><\/figure>\n<p>If you have been reading about<strong> NAD+ and longevity<\/strong>, you have probably seen NMN drips marketed across Tokyo \u2014 and wondered whether the science behind them is as strong as the marketing. It is a fair question, particularly when the treatment is self-pay and the price is not trivial.<\/p>\n<p>This guide explains what NMN drip therapy is, what the published human research does and does not show, what it costs in Tokyo, and who is genuinely a reasonable candidate.<\/p>\n<p><strong>What you&#8217;ll learn in this article:<\/strong><\/p>\n<ul>\n<li>What NMN and NAD+ actually are, in plain language<\/li>\n<li>What controlled human trials have found \u2014 including where results were not significant<\/li>\n<li>How an NMN IV differs from an oral NMN capsule<\/li>\n<li>Current NMN drip pricing at our clinic group in Tokyo<\/li>\n<li>Who is a suitable candidate, and who should hold off<\/li>\n<\/ul>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>What Is NMN Drip Therapy?<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"NMN drip therapy Tokyo: anti-aging IV treatment gu \u2014 What Is NMN Drip Therapy\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_6129233_1788650440.webp\" alt=\"NMN drip therapy Tokyo: anti-aging IV treatment gu \u2014 What Is NMN Drip Therapy\" \/><\/figure>\n<p><strong>NMN<\/strong> stands for beta-nicotinamide mononucleotide. It is a small molecule found naturally in foods such as broccoli, edamame and avocado, and it is a direct precursor of<strong> NAD+<\/strong> (nicotinamide adenine dinucleotide).<\/p>\n<p>NAD+ is a coenzyme every cell uses for energy metabolism, DNA repair and the activity of the sirtuin family of proteins. Tissue NAD+ concentrations are widely reported to fall with age, which is the biological rationale behind supplementing its precursors.<\/p>\n<p>NMN drip therapy delivers NMN dissolved in saline directly into a vein, bypassing digestion. In Japan, NMN is not an approved pharmaceutical: the Ministry of Health, Labour and Welfare&#8217;s 2020 notification on drug\/food classification (\u85ac\u751f\u76e3\u9ebb\u767a0331\u7b2c9\u53f7, 31 March 2020) added beta-nicotinamide mononucleotide to the list of ingredient substances not judged to be pharmaceuticals unless medicinal claims are made. In practical terms, that means NMN drips are entirely self-pay (\u81ea\u7531\u8a3a\u7642) and are not covered by Japanese national health insurance.<\/p>\n<h3>Why the intravenous route is used<\/h3>\n<p>Oral NMN must survive the digestive tract and first-pass liver metabolism. An IV places the molecule straight into the bloodstream, which produces a faster and higher peak in circulating NAD+ precursors than a capsule can.<\/p>\n<p>That is a pharmacokinetic argument, not automatically a clinical one \u2014 and the distinction matters when you are deciding what to spend money on.<\/p>\n<h2>What the Research Actually Shows<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"NMN drip therapy Tokyo: anti-aging IV treatment gu \u2014 What the Research Actually Shows\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_6753445_1788650441.webp\" alt=\"NMN drip therapy Tokyo: anti-aging IV treatment gu \u2014 What the Research Actually Shows\" \/><\/figure>\n<h3>Oral NMN: the stronger evidence base<\/h3>\n<p>Most controlled human data on<strong> NMN<\/strong> comes from oral supplementation. A randomised, double-blind, placebo-controlled study published in <em>GeroScience<\/em> in 2024 gave 60 Japanese adults aged 65\u201375 either 250 mg\/day of NMN or placebo for 12 weeks.<\/p>\n<p>Importantly, the study&#8217;s primary outcome \u2014 a stepping test \u2014 showed no significant difference between groups at 4 or 12 weeks. Secondary outcomes did: the NMN group had significantly higher blood NAD+ and NAD+ metabolite levels, a significantly shorter 4-metre walking time than placebo, and improved sleep quality. Studies suggest a benefit, in other words, but the headline finding was not the trial&#8217;s primary endpoint.<\/p>\n<p>An earlier randomised, double-blind, placebo-controlled trial in <em>Nutrients<\/em> (2022) studied 105 older Japanese adults, mean age around 72.6 years, taking 250 mg\/day for 12 weeks. The group taking NMN in the afternoon showed the largest effect sizes for sleep-related measures and for the five-times sit-to-stand test, although the overall between-group interaction did not reach significance for sleep quality.<\/p>\n<h3>Intravenous NMN: promising but preliminary<\/h3>\n<p>Human data on the IV route is far thinner. The most cited study, published in <em>Cureus<\/em> in 2022, was an open-label, single-arm exploratory trial in 10 healthy volunteers aged 20\u201370, who received 300 mg of NMN in 100 mL of saline infused at 5 mL per minute.<\/p>\n<p>Blood NAD+ rose significantly from 0.5 to 3 hours after infusion, and blood triglycerides fell significantly from 0.5 to 5 hours. No adverse events were seen on electrocardiogram, vital signs, blood counts, or liver, pancreatic, cardiac and renal markers.<\/p>\n<p>Clinical reports of this kind are genuinely encouraging on short-term safety and on the ability of an IV to raise NAD+. They are not, however, placebo-controlled, and ten participants studied over a single day cannot establish long-term anti-ageing outcomes.<\/p>\n<table style=\"border-collapse: collapse; width: 100%; margin: 20px 0; font-size: 0.95em; border: 1px solid #ccc;\">\n<thead>\n<tr>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Feature<\/th>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">NMN IV drip<\/th>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Oral NMN supplement<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Route<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Intravenous infusion, bypasses digestion<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Capsule, subject to digestion and liver metabolism<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Doses used in published human work<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">300 mg single infusion (Cureus, 2022)<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">250 mg\/day for 12 weeks (GeroScience 2024; Nutrients 2022)<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Strength of evidence<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Open-label, single-arm, n=10<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Randomised, double-blind, placebo-controlled<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Time course<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">NAD+ rise within 0.5\u20133 hours<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Measured over weeks of daily intake<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Typical use pattern<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Sessions at 1\u20134 week intervals<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Daily, continuous<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Main practical drawback<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Clinic visit required; higher cost per dose<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Requires consistency; slower onset<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Cost of NMN Drip Therapy in Tokyo<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"NMN drip therapy Tokyo: anti-aging IV treatment gu \u2014 Cost of NMN Drip Therapy in Tokyo\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_6436272_1788650442.webp\" alt=\"NMN drip therapy Tokyo: anti-aging IV treatment gu \u2014 Cost of NMN Drip Therapy in Tokyo\" \/><\/figure>\n<p>NMN drips are self-pay, so pricing varies considerably between clinics and by dose. The figures below are those published on our group&#8217;s official treatment page at the time of writing.<\/p>\n<ul>\n<li>First-time trial infusion: 100 mg \u00a523,000 \/ 200 mg \u00a534,000 \/ 300 mg \u00a546,000<\/li>\n<li>NMN 200 mg: single session \u00a548,000; 5 sessions \u00a5228,000; 10 sessions \u00a5432,000<\/li>\n<li>NMN 300 mg: single session \u00a564,000; 5 sessions \u00a5304,000; 10 sessions \u00a5576,000<\/li>\n<\/ul>\n<p>Oral NMN is also available as an in-clinic supplement (NMN 9000+, 150 mg per capsule, \u00a5162,000 for 60 capsules), which some patients prefer as a daily baseline between infusions.<\/p>\n<p>Prices can change, and package terms and tax treatment should be confirmed directly. Please see the clinic&#8217;s official price page or contact us for a current quote. For an accurate quote, please book a consultation.<\/p>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>What to Expect: Before, During and After<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"NMN drip therapy Tokyo: anti-aging IV treatment gu \u2014 What to Expect: Before, During and After\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_6010936_1788650443.webp\" alt=\"NMN drip therapy Tokyo: anti-aging IV treatment gu \u2014 What to Expect: Before, During and After\" \/><\/figure>\n<p>A first appointment begins with a medical consultation covering your health history, current medication, and what you are hoping to achieve. Blood testing is sometimes suggested where an underlying issue such as anaemia or a nutritional deficiency may be a better explanation for fatigue than low NAD+.<\/p>\n<p>The infusion itself takes approximately 15 to 30 minutes. You sit or recline with a cannula in the arm, and can read or work throughout.<\/p>\n<p>There is no downtime in the surgical sense \u2014 you can return to work or travel plans the same day. The clinic&#8217;s published information lists discomfort along the vein during infusion as the main expected side effect; as with any intravenous line, bruising or tenderness at the puncture site is also possible.<\/p>\n<h3>Who is a reasonable candidate?<\/h3>\n<p>Generally, adults in good health from around their thirties onward who are interested in preventive and anti-ageing care, and who understand that this is an elective, self-pay treatment with evolving evidence. Many patients pair it with orthomolecular (nutritional) therapy or other IV drip therapy such as high-dose vitamin C or glutathione.<\/p>\n<h3>Who should not proceed without careful discussion?<\/h3>\n<p>Anyone who is pregnant or breastfeeding, who has significant liver, kidney or cardiac disease, an active malignancy, or who is taking multiple prescription medications should discuss suitability with a physician first. Published trials excluded participants with malignancies, infections, and psychiatric or metabolic disorders, so evidence in those groups is essentially absent.<\/p>\n<p>If your main complaint is persistent exhaustion, poor sleep or hair loss, a diagnostic work-up should come before an elective infusion \u2014 not after it.<\/p>\n<h2>What People Often Get Wrong About NMN Drips<\/h2>\n<h3>&#8220;NMN is an approved anti-ageing medicine&#8221;<\/h3>\n<p>It is not. In Japan, NMN sits on the MHLW list of substances not judged to be pharmaceuticals unless medicinal claims are made, which is a food-ingredient classification rather than a drug approval. There is no approved indication, no insurance coverage, and clinics cannot lawfully advertise NMN as treating or curing disease.<\/p>\n<h3>&#8220;It&#8217;s FDA-approved, so it must be proven&#8221;<\/h3>\n<p>This conflates two entirely different things. Regulatory analyses report that in letters dated 29 September 2025 the US FDA reversed its earlier position and determined that NMN is not excluded from the definition of a dietary supplement \u2014 a decision about whether an oral supplement may be sold, not an approval of intravenous NMN, and with no bearing on Japanese regulatory status.<\/p>\n<h3>&#8220;An IV must work better than a capsule&#8221;<\/h3>\n<p>An IV certainly raises circulating NAD+ faster. But the randomised, placebo-controlled evidence to date is on oral dosing, and we are not aware of published head-to-head randomised trials comparing IV against oral NMN for clinical outcomes. In consultations at BIOTOPE CLINIC in Shirokanedai, this is one of the most common points Dr. Karibe&#8217;s team walks patients through before booking a course.<\/p>\n<h2>Where to Get NMN Drip Therapy in Tokyo<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"NMN drip therapy Tokyo: anti-aging IV treatment gu \u2014 Where to Get NMN Drip Therapy in Tokyo\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_29023824_1788650445.webp\" alt=\"NMN drip therapy Tokyo: anti-aging IV treatment gu \u2014 Where to Get NMN Drip Therapy in Tokyo\" \/><\/figure>\n<p>Within our clinic group, both<strong> BIOTOPE CLINIC<\/strong> (Shirokanedai, Minato-ku) and <strong>Kojimachi Dermatology &amp; Plastic Surgery Clinic<\/strong> (Ichigaya, Chiyoda-ku) offer English-language consultation with Dr. Jun Karibe&#8217;s team. NMN drip therapy and preventive\/anti-ageing care are handled at <strong>BIOTOPE CLINIC<\/strong> in Shirokanedai, while insurance-covered general dermatology \u2014 eczema, acne, rashes, warts and moles \u2014 is handled at Kojimachi. Bookings and enquiries in English: LINE or WhatsApp.<\/p>\n<p>Related preventive services such as orthomolecular nutritional therapy, gut microbiome analysis and high-dose vitamin C or glutathione IV drips are also available at BIOTOPE CLINIC in Shirokanedai \u2014 feel free to ask about them during a consultation with Dr. Karibe.<\/p>\n<h2>Frequently Asked Questions<\/h2>\n<dl class=\"kj-faq\">\n<dt>Q. How often should NMN drips be repeated?<\/dt>\n<dd>Our clinic&#8217;s published guidance suggests intervals of roughly one to four weeks for patients seeking sustained effects. The appropriate interval depends on your goals and response, and should be set at consultation rather than fixed in advance.<\/dd>\n<dd><\/dd>\n<dt>Q. Will I feel a difference immediately?<\/dt>\n<dd>Some patients report improved energy or sleep, but these are subjective impressions rather than trial endpoints, and no reputable clinic can promise a specific outcome. The one measurable, published short-term change after IV NMN is a rise in blood NAD+ within hours of infusion.<\/dd>\n<dd><\/dd>\n<dt>Q. Is NMN drip therapy covered by Japanese health insurance?<\/dt>\n<dd>No. Because NMN is classified as a non-pharmaceutical ingredient in Japan, drips are entirely self-pay. You should budget for the full listed price, and note that National Health Insurance and most travel insurance will not reimburse elective anti-ageing treatment.<\/dd>\n<dd><\/dd>\n<dt>Q. Can I do this as a visitor to Tokyo on a short trip?<\/dt>\n<dd>Yes \u2014 the session takes about 15 to 30 minutes with no downtime, so a single infusion fits easily into a trip. Both clinics in our group provide English-language consultation, so you can discuss suitability before booking.<\/dd>\n<\/dl>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>Summary<\/h2>\n<p>NMN drip therapy delivers a NAD+ precursor directly into the bloodstream, and the available human data indicates it is well tolerated in the short term and does raise blood NAD+ within hours.<\/p>\n<p>The stronger randomised evidence, however, sits with oral NMN at around 250 mg daily over 12 weeks, where trials have shown higher NAD+ levels and some measures of walking speed and sleep quality improving \u2014 while primary endpoints have not always reached significance. Treat NMN as a reasonable, evidence-informed option within preventive care, not as a proven anti-ageing cure.<\/p>\n<p>If you have questions about NMN drip therapy, both BIOTOPE CLINIC (Shirokanedai, Minato-ku) and Kojimachi Dermatology &amp; Plastic Surgery Clinic (Ichigaya, Chiyoda-ku) offer English-language consultation with Dr. Karibe and his team. NMN drip therapy is primarily handled at BIOTOPE CLINIC in Shirokanedai. English enquiries: LINE or WhatsApp.<\/p>\n<div class=\"kjmc-en-booking-box\" style=\"background: linear-gradient(135deg,#f1faf3 0%,#e6f3ea 100%); border-radius: 14px; padding: 32px 24px; margin: 36px 0 24px; border: 1px solid #c5dccd; text-align: center;\">\n<h3 style=\"margin: 0 0 8px; color: #3a6e3a; border: none; padding: 0; font-size: 1.3em;\">24\/7 Consultation &amp; Booking<\/h3>\n<div style=\"width: 48px; height: 2px; background: #3a6e3a; margin: 0 auto 22px;\"><\/div>\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 1.1em; font-weight: bold;\">Book a Consultation or Treatment<\/p>\n<p style=\"margin: 0 0 24px; color: #2c4a35; line-height: 1.75;\">Our English-speaking team responds via LINE or WhatsApp \u2014 usually the same day.<\/p>\n<p style=\"margin: 0 0 10px; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; justify-content: center; gap: 10px; background: #06C755; color: #fff; padding: 14px 32px; border-radius: 10px; text-decoration: none; font-weight: bold; font-size: 1.02em; box-shadow: 0 2px 8px rgba(6,199,85,0.25); min-width: 240px; white-space: nowrap;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; justify-content: center; gap: 10px; background: #25D366; color: #fff; padding: 14px 32px; border-radius: 10px; text-decoration: none; font-weight: bold; font-size: 1.02em; box-shadow: 0 2px 8px rgba(37,211,102,0.25); min-width: 240px; white-space: nowrap;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>References<\/h2>\n<ol>\n<li>Kimura S, Ichikawa M, Sugawara S, Katagiri T, Hirasawa Y, Ishikawa T, Matsunaga W, Gotoh A. Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals. Cureus. 2022.<\/li>\n<li>Morifuji M, Higashi S, Ebihara S, Nagata M. Ingestion of \u03b2-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study. GeroScience. 2024;46(5):4671\u20134688.<\/li>\n<li>Kim M, et al. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022;14(4):755.<\/li>\n<li>Ministry of Health, Labour and Welfare, Japan. Examples of the handling of ingredient substances (raw materials) in the drug\/food classification (\u85ac\u751f\u76e3\u9ebb\u767a0331\u7b2c9\u53f7). 31 March 2020.<\/li>\n<li>Venable LLP. FDA Declares Nicotinamide Mononucleotide Is a Dietary Supplement. 2025.<\/li>\n<\/ol>\n<h2>Related Articles<\/h2>\n<p>You may also find these articles useful.<\/p>\n<ul>\n<li><a href=\"https:\/\/kojihifu.com\/english\/nad-iv-tokyo-english-clinic-comparison\/\" target=\"_blank\" rel=\"noopener\">Where to Get NAD+ IV in Tokyo (2026 English-Speaking Clinic Guide)<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/nmn-vs-nad-japan\/\" target=\"_blank\" rel=\"noopener\">NMN vs NAD+ in Japan: Which Should You Actually Take?<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/iv-vitamin-drip-tokyo-expats-3\/\" target=\"_blank\" rel=\"noopener\">IV Vitamin Drip Tokyo: Wellness Treatment for Expats<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/iv-vitamin-drip-tokyo-expats\/\" target=\"_blank\" rel=\"noopener\">IV Vitamin Drip Tokyo: Wellness Treatment for Expats<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/anti-aging-treatments-tokyo-expats\/\" target=\"_blank\" rel=\"noopener\">Anti-Aging Treatments Tokyo: Complete Guide for Expats<\/a><\/li>\n<\/ul>\n<div style=\"margin: 2.5em 0 1em; padding: 1.5em; border: 1px solid #d5d5d5; border-radius: 10px; background: #fafafa; font-size: .9em;\">\n<p style=\"font-size: .72em; font-weight: bold; color: #888; margin: 0 0 1.2em; letter-spacing: .08em;\">SUPERVISED BY<\/p>\n<div style=\"display: flex; align-items: flex-start; gap: 1.2em; flex-wrap: wrap;\">\n<div style=\"flex-shrink: 0; text-align: center; min-width: 110px;\"><img decoding=\"async\" style=\"width: 100px; height: 100px; border-radius: 50%; object-fit: cover; object-position: top center; display: block; margin: 0 auto; border: 3px solid #e0e0e0;\" src=\"https:\/\/kojihifu.com\/hon\/wp-content\/uploads\/2022\/01\/photo-karibejun-400-3_re-300x300.jpg\" alt=\"Dr. Jun Karibe MD \u2014 Board-certified Plastic Surgeon, Director of Kojimachi Dermatology &amp; Plastic Surgery Clinic\" \/><\/p>\n<p style=\"margin: .6em 0 .1em; font-weight: bold; font-size: .95em; color: #222;\">Dr. Jun Karibe<\/p>\n<p style=\"margin: 0 0 .1em; font-size: .75em; color: #999;\">MD<\/p>\n<p style=\"margin: 0; font-size: .75em; color: #555; font-weight: bold;\">Director<\/p>\n<\/div>\n<div style=\"flex: 1; min-width: 200px;\">\n<div style=\"margin-bottom: .75em; background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Education &amp; Career<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Juntendo University School of Medicine<\/div>\n<div>Department of Plastic Surgery, University of Tokyo Hospital<\/div>\n<div>Assistant Professor, Plastic &amp; Cosmetic Surgery, Saitama Medical University<\/div>\n<div>Assistant Professor &amp; Chief Resident, Yamanashi University Hospital<\/div>\n<div>2019: Founded Kojimachi Dermatology &amp; Plastic Surgery Clinic (Ichigaya, Tokyo)<\/div>\n<div>2021: Founded BIOTOPE CLINIC Shirokanedai (Minato-ku, Tokyo)<\/div>\n<\/div>\n<\/div>\n<div style=\"margin-bottom: .75em; background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Certifications<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Board-certified Plastic Surgeon \u2014 Japan Society of Plastic and Reconstructive Surgery<\/div>\n<div>Specialist \u2014 Japan Society of Anti-Aging Medicine<\/div>\n<div>Certified Industrial Physician \u2014 Japan Medical Association<\/div>\n<div>Allergan VST-certified Injector (Botox &amp; Hyaluronic Acid)<\/div>\n<\/div>\n<\/div>\n<div style=\"background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Awards<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Best Presentation Award \u2014 Dept. of Plastic Surgery, University of Tokyo (2016)<\/div>\n<div>Excellence Award \u2014 Japan Society of Plastic and Reconstructive Surgery (2018)<\/div>\n<div>Featured Presentation \u2014 ASPS Annual Scientific Meeting, USA (2018)<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"margin-top: 1em; padding-top: .75em; border-top: 1px solid #e8e8e8; display: flex; flex-wrap: wrap; align-items: center; gap: .5em;\"><a style=\"display: inline-block; background: #e1306c; color: #fff; padding: .4em .9em; border-radius: 4px; text-decoration: none; font-size: .8em; font-weight: bold;\" href=\"https:\/\/www.instagram.com\/dr.jun_\/\" target=\"_blank\" rel=\"noopener noreferrer\">Instagram<\/a><\/p>\n<div style=\"margin-top: 1em; padding-top: .75em; border-top: 1px dashed #d5d5d5; font-size: .78em; color: #555; line-height: 1.7;\">\n<p style=\"margin: 0 0 .3em; font-size: .72em; font-weight: bold; color: #888; letter-spacing: .08em;\">MEDICAL REVIEW<\/p>\n<div><strong>Jun Karibe, MD<\/strong> \u2014 Board-certified Plastic Surgeon \u2014 Japan Society of Plastic and Reconstructive Surgery<\/div>\n<div>Medical Director, BIOTOPE CLINIC<\/div>\n<div>Last medically reviewed: 2026-09-06<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"NMN drip therapy in Tokyo: an evidence-based anti-aging IV treatment guide covering NAD+ science, costs, and candidacy. 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