{"id":11842,"date":"2026-09-10T13:03:41","date_gmt":"2026-09-10T04:03:41","guid":{"rendered":"https:\/\/kojihifu.com\/english\/?p=11842"},"modified":"2026-09-10T13:03:43","modified_gmt":"2026-09-10T04:03:43","slug":"hyaluronidase-tokyo-dissolving-ha-filler","status":"publish","type":"post","link":"https:\/\/kojihifu.com\/english\/hyaluronidase-tokyo-dissolving-ha-filler\/","title":{"rendered":"Hyaluronidase in Tokyo: A Guide to Dissolving HA Filler"},"content":{"rendered":"<p><script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"MedicalWebPage\",\"@id\":\"https:\/\/kojihifu.com\/english\/hyaluronidase-tokyo-dissolving-ha-filler\/#webpage\",\"url\":\"https:\/\/kojihifu.com\/english\/hyaluronidase-tokyo-dissolving-ha-filler\/\",\"name\":\"Hyaluronidase in Tokyo: A Guide to Dissolving HA Filler\",\"inLanguage\":\"en\",\"isPartOf\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#website\"},\"about\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#clinic-biotope\"},\"reviewedBy\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#physician-karibe\"},\"lastReviewed\":\"2026-09-10\"},{\"@type\":[\"Article\",\"MedicalWebPage\"],\"@id\":\"https:\/\/kojihifu.com\/english\/hyaluronidase-tokyo-dissolving-ha-filler\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/kojihifu.com\/english\/hyaluronidase-tokyo-dissolving-ha-filler\/#webpage\"},\"headline\":\"Hyaluronidase in Tokyo: A Guide to Dissolving HA Filler\",\"url\":\"https:\/\/kojihifu.com\/english\/hyaluronidase-tokyo-dissolving-ha-filler\/\",\"inLanguage\":\"en\",\"author\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#physician-karibe\"},\"reviewedBy\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#physician-karibe\"},\"publisher\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#organization\"},\"mainEntityOfPage\":{\"@id\":\"https:\/\/kojihifu.com\/english\/hyaluronidase-tokyo-dissolving-ha-filler\/#webpage\"},\"description\":\"Hyaluronidase in Tokyo explained: how human and animal-derived enzymes dissolve HA filler, realistic timelines, costs and risks. Message us in English today.\",\"datePublished\":\"2026-09-10\",\"dateModified\":\"2026-09-10\",\"lastReviewed\":\"2026-09-10\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/kojihifu.com\/english\/hyaluronidase-tokyo-dissolving-ha-filler\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/kojihifu.com\/english\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Skin & Dermatology\",\"item\":\"https:\/\/kojihifu.com\/english\/column\/skin-dermatology\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Hyaluronidase in Tokyo: A Guide to Dissolving HA Filler\",\"item\":\"https:\/\/kojihifu.com\/english\/hyaluronidase-tokyo-dissolving-ha-filler\/\"}]}]}<\/script><br \/>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"Does dissolving filler make my skin sag afterwards?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Some patients notice temporary laxity or hollowing because the volume that was supporting the tissue has been removed and the area is still swollen. Most of this settles over one to two weeks, though tissue that has been stretched by long-standing over-filling may not return fully to its previous state.\"}}, {\"@type\": \"Question\", \"name\": \"Can hyaluronidase dissolve filler injected years ago?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Yes, it can \u2014 older deposits are frequently found to still be present. However, filler that has become encapsulated over time creates a physical barrier to enzyme diffusion, so more sessions are often required than for recent filler.\"}}, {\"@type\": \"Question\", \"name\": \"Is a skin test necessary before treatment?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Published aesthetic guidance does not recommend routine screening tests for every patient, and suggests intradermal testing (using 15 units) only where the clinical history raises suspicion of allergy. Patients with a history of bee or wasp sting allergy should be assessed at a specialist allergy clinic first.\"}}, {\"@type\": \"Question\", \"name\": \"How soon can I have new filler after dissolving?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Guidance recommends waiting a minimum of two weeks so that swelling resolves and the true tissue contour becomes visible. Re-injecting before that risks building on a distorted foundation.\"}}]}<\/script><\/p>\n<h2>Hyaluronidase in Tokyo: A Complete Guide to Dissolving Hyaluronic Acid Filler<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Hyaluronidase in Tokyo: complete guide to dissolvi \u2014 Hyaluronidase in Tokyo: A Complete Guide to Dissolving Hyalu\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_7581583_1789009072.webp\" alt=\"Hyaluronidase in Tokyo: complete guide to dissolvi \u2014 Hyaluronidase in Tokyo: A Complete Guide to Dissolving Hyalu\" \/><\/figure>\n<p>If you are unhappy with a<strong> hyaluronic acid (HA) filler result<\/strong> \u2014 a lip that looks heavier than you wanted, a lump under the eye, or a face that simply no longer looks like yours \u2014 it is natural to want it gone quickly. Hyaluronidase, the enzyme used to break down HA filler, is the tool clinicians reach for, but it is neither a simple undo button nor a risk-free one.<\/p>\n<p>This guide explains what hyaluronidase is, how human-derived (recombinant) and animal-derived products differ, what results and timelines are realistic, what it costs in Tokyo, and who should think twice before having it.<\/p>\n<p><strong>What you&#8217;ll learn in this article:<\/strong><\/p>\n<ul>\n<li>What hyaluronidase is and why its use for filler reversal is off-label worldwide<\/li>\n<li>The practical difference between recombinant human and animal-derived (ovine or bovine) hyaluronidase<\/li>\n<li>How quickly filler breaks down \u2014 and why some fillers resist dissolution<\/li>\n<li>Current published pricing at our Tokyo clinic group, plus consultation fees<\/li>\n<li>Two things patients commonly get wrong about &#8220;dissolving&#8221; filler<\/li>\n<\/ul>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>What Is Hyaluronidase, and How Does It Work?<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Hyaluronidase in Tokyo: complete guide to dissolvi \u2014 What Is Hyaluronidase, and How Does It Work\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_7446679_1789009074.webp\" alt=\"Hyaluronidase in Tokyo: complete guide to dissolvi \u2014 What Is Hyaluronidase, and How Does It Work\" \/><\/figure>\n<p><strong>Hyaluronidase<\/strong> is a family of enzymes that cleave hyaluronic acid, the sugar-based molecule that gives HA fillers their volume and that also occurs naturally throughout human skin and connective tissue. When injected into a filler deposit, the enzyme breaks the gel down into fragments small enough for the body to clear.<\/p>\n<p>Medically, hyaluronidase has been used for decades as a &#8220;spreading agent&#8221; \u2014 to help injected drugs and subcutaneous fluids disperse. Its use to reverse cosmetic HA filler is off-label in every major market, including Japan and the United States, meaning no regulator has formally approved a hyaluronidase product for that specific purpose.<\/p>\n<h3>Regulatory status in Japan: what you should know before consenting<\/h3>\n<p>No hyaluronidase product carries a Japanese marketing approval for dissolving cosmetic filler, so clinics in Japan obtain it as an unapproved drug, typically through physician-led import. This is legal, but it carries obligations.<\/p>\n<p>Japan&#8217;s Ministry of Health, Labour and Welfare requires clinics advertising treatments that use unapproved drugs to disclose four things: that the drug is unapproved under the Pharmaceuticals and Medical Devices Act, how it was obtained (including whether by personal import), whether a domestically approved equivalent exists, and safety information from overseas regulators. A clinic that cannot answer those questions clearly is not a clinic you should hand your face to.<\/p>\n<h2>Human-Derived vs Animal-Derived Hyaluronidase<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Hyaluronidase in Tokyo: complete guide to dissolvi \u2014 Human-Derived vs Animal-Derived Hyaluronidase\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_16131210_1789009075.webp\" alt=\"Hyaluronidase in Tokyo: complete guide to dissolvi \u2014 Human-Derived vs Animal-Derived Hyaluronidase\" \/><\/figure>\n<p>This is the single most common question English-speaking patients bring to a filler-reversal consultation in Tokyo, and it is a reasonable one.<\/p>\n<p>The enzyme itself does the same job; the difference lies in how it is manufactured and what else comes along with it.<\/p>\n<p>Animal-derived hyaluronidase is extracted and purified from ovine (sheep) or bovine (cattle) testicular tissue. Recombinant human hyaluronidase is produced by genetically engineered cell lines rather than harvested from animal tissue, which removes animal protein impurities from the equation.<\/p>\n<table style=\"border-collapse: collapse; width: 100%; margin: 20px 0; font-size: 0.95em; border: 1px solid #ccc;\">\n<thead>\n<tr>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Feature<\/th>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Recombinant human hyaluronidase<\/th>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Animal-derived (ovine or bovine)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">How it is made<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Produced by engineered cell culture; no animal tissue extraction<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Extracted and purified from sheep or cattle testicular tissue<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Approved indications (overseas)<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Adjunct to disperse injected drugs and subcutaneous fluids<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Same category of indications<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Approved for filler reversal?<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">No \u2014 off-label everywhere<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">No \u2014 off-label everywhere<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Approved in Japan for this use?<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">No<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">No<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Immunogenicity data<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Antibody formation studied across multiple trials; in one published analysis, 3\u201312% of participants had pre-existing antibodies and 2\u201318% developed treatment-induced antibodies, with no association with adverse events<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Allergy risk is generally attributed to residual protein impurities from tissue extraction; published aesthetic guidance describes the recombinant formulation as the purest option<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Practical notes<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Usually higher acquisition cost; often preferred for patients with animal-protein or venom allergy concerns<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Widely used and well described in the aesthetic literature; lower cost<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Note: neither type is allergy-free. Published UK aesthetic guidance stresses that patients with a history of bee or wasp sting allergy should be assessed at a specialist allergy clinic before elective dissolution, because of anaphylaxis risk. Every session should be performed where adrenaline and resuscitation equipment are immediately available.<\/p>\n<h2>Expected Results and Realistic Timelines<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Hyaluronidase in Tokyo: complete guide to dissolvi \u2014 Expected Results and Realistic Timelines\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_4586709_1789009077.webp\" alt=\"Hyaluronidase in Tokyo: complete guide to dissolvi \u2014 Expected Results and Realistic Timelines\" \/><\/figure>\n<p><strong>Hyaluronidase<\/strong> begins working within minutes, but &#8220;working&#8221; and &#8220;finished&#8221; are not the same thing.<\/p>\n<p>A 2025 review in <em>Plastic and Reconstructive Surgery \u2013 Global Open<\/em> describes biphasic (particulate) fillers integrating with hyaluronidase solution in roughly <strong>five minutes,<\/strong> with near-complete dissolution in one to two hours, while monophasic (smooth gel) fillers may need about an hour for the solution to penetrate and <strong>up to 24 hours for full breakdown<\/strong>.<\/p>\n<p>For elective correction, published guidance recommends &#8220;treating to effect&#8221; rather than fixed doses, using concentrations of not less than 1,500 units in 5 mL, and reassessing at 48 hours before deciding whether a second session is needed. The same review reports typical figures of roughly 600\u2013750 units per millilitre of monophasic filler as a starting reference.<\/p>\n<p>Swelling from the enzyme itself distorts the result for <strong>several days<\/strong>, so the honest answer to &#8220;when will I see the final shape?&#8221; is one to two weeks. Guidance also recommends waiting a minimum of two weeks before re-injecting new filler, which allows swelling to settle and gives a more predictable aesthetic outcome.<\/p>\n<h3>Emergency use: vascular occlusion<\/h3>\n<p><strong>Hyaluronidase<\/strong> is also the emergency treatment when filler blocks a blood vessel \u2014 a rare but serious complication that can cause skin necrosis or, exceptionally, visual loss. Published protocols describe infiltrating 450\u20131,500 units over the affected territory and repeating at 30\u201360 minute intervals while vascular compromise persists. This is a same-hour emergency, not a next-week booking.<\/p>\n<h2>Cost of Hyaluronidase in Tokyo<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Hyaluronidase in Tokyo: complete guide to dissolvi \u2014 Cost of Hyaluronidase in Tokyo\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_9157201_1789009078.webp\" alt=\"Hyaluronidase in Tokyo: complete guide to dissolvi \u2014 Cost of Hyaluronidase in Tokyo\" \/><\/figure>\n<p>Within our clinic group, hyaluronidase is charged by volume of enzyme solution used. According to the group&#8217;s published price list (effective 1 October 2023, all figures tax-included), hyaluronidase is <strong>\u00a511,000 per 0.1 mL<\/strong>, and <strong>\u00a522,000 per 0.1 mL<\/strong> where the filler being dissolved was placed at another clinic.<\/p>\n<p>The higher figure for outside filler reflects genuine extra work: when the product, the volume and the injection plane are unknown, assessment and dosing take longer and repeat sessions are more likely.<\/p>\n<p>Consultation fees are listed separately at <strong>\u00a55,500<\/strong> for first and follow-up visits, with a <strong>\u00a52,200<\/strong> designation fee for a cosmetic surgery counselling appointment with Dr. Karibe (no designation fee applies for cosmetic dermatology). Because total cost depends on how much enzyme a given deposit requires, please see the clinic&#8217;s official price page for current figures. For an accurate quote, please book a consultation.<\/p>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>What to Expect: Before, During and After<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Hyaluronidase in Tokyo: complete guide to dissolvi \u2014 What to Expect: Before, During and After\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_7581577_1789009079.webp\" alt=\"Hyaluronidase in Tokyo: complete guide to dissolvi \u2014 What to Expect: Before, During and After\" \/><\/figure>\n<h3>Before<\/h3>\n<p>Expect questions about which filler was used, when, in what plane, and by whom \u2014 bring records or photographs if you have them. Disclose any history of drug allergy, insect-sting allergy, or previous hyaluronidase exposure. Published guidance advises against injecting hyaluronidase within 48 hours of botulinum toxin, and against injecting into actively infected tissue except under specific circumstances.<\/p>\n<h3>During<\/h3>\n<p>The enzyme is injected through a fine needle or cannula directly into the filler deposit, often with local anaesthetic and followed by firm massage to help the solution mix with the gel. Most sessions take 10\u201320 minutes. Because filler can be encapsulated and hard to reach, some clinicians use ultrasound to place the enzyme precisely.<\/p>\n<h3>After<\/h3>\n<p>Downtime is usually modest: swelling, redness and occasional bruising for two to five days. The treated area often looks flatter or more hollow than the pre-filler baseline for one to two weeks before tissue settles. Repeat sessions are common and are not a sign that something went wrong.<\/p>\n<h2>Who Is a Good Candidate \u2014 and Who Should Avoid It?<\/h2>\n<p>Good candidates include patients with over-filled or migrated HA filler, visible lumps or nodules, filler placed too superficially (including bluish Tyndall discolouration under the eye), or anyone needing urgent management of suspected vascular occlusion.<\/p>\n<p>Caution or avoidance applies to patients with known hypersensitivity to hyaluronidase, a history of severe insect-sting allergy without prior allergy assessment, active infection at the site, or pregnancy and breastfeeding, where safety data are limited. Crucially, hyaluronidase does nothing for non-HA fillers such as calcium hydroxylapatite, poly-L-lactic acid or permanent products \u2014 if you do not know what was injected, that must be established first.<\/p>\n<p>At<strong> BIOTOPE CLINIC<\/strong> in Shirokanedai, filler-correction consultations usually begin with exactly that question, because identifying the product determines whether hyaluronidase is even the right tool. Where volume loss after dissolution is the real concern, non-filler options such as HIFU or Morpheus8 radiofrequency microneedling are sometimes discussed instead \u2014 these are available at <strong>BIOTOPE CLINIC<\/strong>, and you are welcome to ask about them during a consultation with Dr. Karibe&#8217;s team.<\/p>\n<h2>What People Often Get Wrong About Dissolving Filler<\/h2>\n<h3>Misconception 1: &#8220;One session removes all of it.&#8221;<\/h3>\n<p><strong>Hyaluronidase<\/strong> has to physically reach the gel to act on it, and cross-linked filler resists that. A 2026 letter in the <em>Journal of Cosmetic Dermatology<\/em> explains that dense polymer networks, small pore size, and encapsulation of older filler deposits all restrict enzyme diffusion, so &#8220;diffusion alone is insufficient to ensure enzymatic contact with the entire gel mass.&#8221;<\/p>\n<p>Laboratory work supports this. In a standardised in vitro study published in <em>European Journal of Medical Research<\/em>, three comparable HA fillers exposed to bovine hyaluronidase at 10 U\/mL behaved very differently: one showed degradation from 5 hours (statistically significant from 14 hours), a second from 7 hours (significant from 13 hours), and a third showed no significant degradation at all. The most resistant product had the highest HA concentration (24 mg\/mL), and the authors concluded that HA content and cross-linking technique \u2014 not whether a filler is monophasic or biphasic \u2014 determine hyaluronidase sensitivity.<\/p>\n<h3>Misconception 2: &#8220;It only touches the filler, so it is harmless.&#8221;<\/h3>\n<p>Hyaluronidase is not selective. It acts on hyaluronic acid it encounters, which includes the hyaluronic acid native to your own skin and connective tissue, and its enzymatic activity can persist for several hours after injection. That is why published guidance emphasises treating to effect with careful placement rather than flooding an area, and why a two-week wait before re-injection is advised.<\/p>\n<p>Allergic reactions are uncommon but real, and hypersensitivity has been documented with both animal-derived and, less frequently, recombinant preparations. &#8220;Uncommon&#8221; is not &#8220;impossible,&#8221; which is why the setting and the operator matter more than the price per unit.<\/p>\n<h2>Where to Get Hyaluronidase Treatment in Tokyo<\/h2>\n<p>Within our clinic group, both BIOTOPE CLINIC (Shirokanedai, Minato-ku) and Kojimachi Dermatology &amp; Plastic Surgery Clinic (Ichigaya, Chiyoda-ku) offer English-language consultation with Dr. Jun Karibe&#8217;s team. Hyaluronidase treatment for dissolving HA filler is handled at BIOTOPE CLINIC in Shirokanedai, the group&#8217;s cosmetic dermatology, cosmetic surgery and men&#8217;s health branch. Bookings and enquiries in English: LINE or WhatsApp.<\/p>\n<p><strong>Kojimachi Dermatology &amp; Plastic Surgery Clinic<\/strong>, the group&#8217;s main office, focuses on insurance-covered general dermatology \u2014 eczema, acne, rashes, warts and moles \u2014 as well as general and aesthetic plastic surgery. If a filler-related concern turns out to be an infection or an inflammatory skin problem rather than a filler problem, care can be coordinated between the two sites.<\/p>\n<h2>Frequently Asked Questions<\/h2>\n<dl class=\"kj-faq\">\n<dt>Q. Does dissolving filler make my skin sag afterwards?<\/dt>\n<dd>Some patients notice temporary laxity or hollowing because the volume that was supporting the tissue has been removed and the area is still swollen. Most of this settles over one to two weeks, though tissue that has been stretched by long-standing over-filling may not return fully to its previous state.<\/dd>\n<dd><\/dd>\n<dt>Q. Can hyaluronidase dissolve filler injected years ago?<\/dt>\n<dd>Yes, it can \u2014 older deposits are frequently found to still be present. However, filler that has become encapsulated over time creates a physical barrier to enzyme diffusion, so more sessions are often required than for recent filler.<\/dd>\n<dd><\/dd>\n<dt>Q. Is a skin test necessary before treatment?<\/dt>\n<dd>Published aesthetic guidance does not recommend routine screening tests for every patient, and suggests intradermal testing (using 15 units) only where the clinical history raises suspicion of allergy. Patients with a history of bee or wasp sting allergy should be assessed at a specialist allergy clinic first.<\/dd>\n<dd><\/dd>\n<dt>Q. How soon can I have new filler after dissolving?<\/dt>\n<dd>Guidance recommends waiting a minimum of two weeks so that swelling resolves and the true tissue contour becomes visible. Re-injecting before that risks building on a distorted foundation.<\/dd>\n<\/dl>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>Summary<\/h2>\n<p><strong>Hyaluronidase<\/strong> is the only established way to reverse HA filler, and it is genuinely valuable \u2014 both for correcting unwanted aesthetic results and as emergency treatment for vascular occlusion. It is also used off-label everywhere, unapproved in Japan for this purpose, unselective in what it breaks down, and less complete in its effect than most patients expect.<\/p>\n<p>A sound plan starts with identifying which filler is actually present, choosing between recombinant human and animal-derived enzyme based on your allergy history and the clinical situation, expecting to reassess at 48 hours, and allowing at least two weeks before any new injection. Cost should be the last variable you optimise, not the first.<\/p>\n<p>If you have questions about hyaluronidase and dissolving hyaluronic acid filler, both<strong> BIOTOPE CLINIC<\/strong> (Shirokanedai, Minato-ku) and <strong>Kojimachi Dermatology &amp; Plastic Surgery Clinic<\/strong> (Ichigaya, Chiyoda-ku) offer English-language consultation with Dr. Karibe and his team. Hyaluronidase treatment is primarily handled at <strong>BIOTOPE CLINIC<\/strong> in Shirokanedai. English enquiries: LINE or WhatsApp.<\/p>\n<div class=\"kjmc-en-booking-box\" style=\"background: linear-gradient(135deg,#f1faf3 0%,#e6f3ea 100%); border-radius: 14px; padding: 32px 24px; margin: 36px 0 24px; border: 1px solid #c5dccd; text-align: center;\">\n<h3 style=\"margin: 0 0 8px; color: #3a6e3a; border: none; padding: 0; font-size: 1.3em;\">24\/7 Consultation &amp; Booking<\/h3>\n<div style=\"width: 48px; height: 2px; background: #3a6e3a; margin: 0 auto 22px;\"><\/div>\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 1.1em; font-weight: bold;\">Book a Consultation or Treatment<\/p>\n<p style=\"margin: 0 0 24px; color: #2c4a35; line-height: 1.75;\">Our English-speaking team responds via LINE or WhatsApp \u2014 usually the same day.<\/p>\n<p style=\"margin: 0 0 10px; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; justify-content: center; gap: 10px; background: #06C755; color: #fff; padding: 14px 32px; border-radius: 10px; text-decoration: none; font-weight: bold; font-size: 1.02em; box-shadow: 0 2px 8px rgba(6,199,85,0.25); min-width: 240px; white-space: nowrap;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; justify-content: center; gap: 10px; background: #25D366; color: #fff; padding: 14px 32px; border-radius: 10px; text-decoration: none; font-weight: bold; font-size: 1.02em; box-shadow: 0 2px 8px rgba(37,211,102,0.25); min-width: 240px; white-space: nowrap;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>References<\/h2>\n<ol>\n<li>Murray G, Convery C, Walker L, Davies E. Guideline for the Safe Use of Hyaluronidase in Aesthetic Medicine, Including Modified High-dose Protocol. Journal of Clinical and Aesthetic Dermatology. 2021;14(8):E69\u2013E75.<\/li>\n<li>Yi KH, Wan J, Yoon SE. Considerations for Proper Use of Hyaluronidase in the Management of Hyaluronic Acid Fillers. Plastic and Reconstructive Surgery \u2013 Global Open. 2025;13(3):e6566.<\/li>\n<li>Buhren BA, Schrumpf H, B\u00f6lke E, Kammers K, Gerber PA. Standardized in vitro analysis of the degradability of hyaluronic acid fillers by hyaluronidase. European Journal of Medical Research. 2018;23:37.<\/li>\n<li>Rosengren S, Dychter SS, Printz MA, et al. Clinical Immunogenicity of rHuPH20, a Hyaluronidase Enabling Subcutaneous Drug Administration. The AAPS Journal. 2015;17(5).<\/li>\n<li>Murray G, Khoshnaw S, Velthuis P. Dissolving Hyaluronic Acid Filler: The Diffusion Barrier to Hyaluronidase Efficacy. Journal of Cosmetic Dermatology. 2026;25(4):e70818.<\/li>\n<\/ol>\n<h2>Related Articles<\/h2>\n<p>You may also find these articles useful.<\/p>\n<ul>\n<li><a href=\"https:\/\/kojihifu.com\/english\/dermal-filler-tokyo-price-guide-2\/\" target=\"_blank\" rel=\"noopener\">Dermal Filler Tokyo: Price Guide &amp; Clinic Selection Tips<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/under-eye-filler-tokyo-risks-benefits-3\/\" target=\"_blank\" rel=\"noopener\">Under Eye Filler Tokyo: Risks, Benefits &amp; Costs<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/lip-filler-tokyo-cost-guide-3\/\" target=\"_blank\" rel=\"noopener\">Lip Filler Tokyo: Cost, Treatment &amp; Clinic Guide<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/ha-filler-tokyo-downtime-stay-flying\/\" target=\"_blank\" rel=\"noopener\">How Long Should You Stay in Tokyo for HA Filler? Downtime, Bruising &amp; Flying Guide<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/volnewmer-jawline-cheeks-tokyo\/\" target=\"_blank\" rel=\"noopener\">Filler for Jawline and Cheeks Tokyo<\/a><\/li>\n<\/ul>\n<div style=\"margin: 2.5em 0 1em; padding: 1.5em; border: 1px solid #d5d5d5; border-radius: 10px; background: #fafafa; font-size: .9em;\">\n<p style=\"font-size: .72em; font-weight: bold; color: #888; margin: 0 0 1.2em; letter-spacing: .08em;\">SUPERVISED BY<\/p>\n<div style=\"display: flex; align-items: flex-start; gap: 1.2em; flex-wrap: wrap;\">\n<div style=\"flex-shrink: 0; text-align: center; min-width: 110px;\"><img decoding=\"async\" style=\"width: 100px; height: 100px; border-radius: 50%; object-fit: cover; object-position: top center; display: block; margin: 0 auto; border: 3px solid #e0e0e0;\" src=\"https:\/\/kojihifu.com\/hon\/wp-content\/uploads\/2022\/01\/photo-karibejun-400-3_re-300x300.jpg\" alt=\"Dr. Jun Karibe MD \u2014 Board-certified Plastic Surgeon, Director of Kojimachi Dermatology &amp; Plastic Surgery Clinic\" \/><\/p>\n<p style=\"margin: .6em 0 .1em; font-weight: bold; font-size: .95em; color: #222;\">Dr. Jun Karibe<\/p>\n<p style=\"margin: 0 0 .1em; font-size: .75em; color: #999;\">MD<\/p>\n<p style=\"margin: 0; font-size: .75em; color: #555; font-weight: bold;\">Director<\/p>\n<\/div>\n<div style=\"flex: 1; min-width: 200px;\">\n<div style=\"margin-bottom: .75em; background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Education &amp; Career<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Juntendo University School of Medicine<\/div>\n<div>Department of Plastic Surgery, University of Tokyo Hospital<\/div>\n<div>Assistant Professor, Plastic &amp; Cosmetic Surgery, Saitama Medical University<\/div>\n<div>Assistant Professor &amp; Chief Resident, Yamanashi University Hospital<\/div>\n<div>2019: Founded Kojimachi Dermatology &amp; Plastic Surgery Clinic (Ichigaya, Tokyo)<\/div>\n<div>2021: Founded BIOTOPE CLINIC Shirokanedai (Minato-ku, Tokyo)<\/div>\n<\/div>\n<\/div>\n<div style=\"margin-bottom: .75em; background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Certifications<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Board-certified Plastic Surgeon \u2014 Japan Society of Plastic and Reconstructive Surgery<\/div>\n<div>Specialist \u2014 Japan Society of Anti-Aging Medicine<\/div>\n<div>Certified Industrial Physician \u2014 Japan Medical Association<\/div>\n<div>Allergan VST-certified Injector (Botox &amp; Hyaluronic Acid)<\/div>\n<\/div>\n<\/div>\n<div style=\"background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Awards<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Best Presentation Award \u2014 Dept. of Plastic Surgery, University of Tokyo (2016)<\/div>\n<div>Excellence Award \u2014 Japan Society of Plastic and Reconstructive Surgery (2018)<\/div>\n<div>Featured Presentation \u2014 ASPS Annual Scientific Meeting, USA (2018)<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"margin-top: 1em; padding-top: .75em; border-top: 1px solid #e8e8e8; display: flex; flex-wrap: wrap; align-items: center; gap: .5em;\"><a style=\"display: inline-block; background: #e1306c; color: #fff; padding: .4em .9em; border-radius: 4px; text-decoration: none; font-size: .8em; font-weight: bold;\" href=\"https:\/\/www.instagram.com\/dr.jun_\/\" target=\"_blank\" rel=\"noopener noreferrer\">Instagram<\/a><\/p>\n<div style=\"margin-top: 1em; padding-top: .75em; border-top: 1px dashed #d5d5d5; font-size: .78em; color: #555; line-height: 1.7;\">\n<p style=\"margin: 0 0 .3em; font-size: .72em; font-weight: bold; color: #888; letter-spacing: .08em;\">MEDICAL REVIEW<\/p>\n<div><strong>Jun Karibe, MD<\/strong> \u2014 Board-certified Plastic Surgeon \u2014 Japan Society of Plastic and Reconstructive Surgery<\/div>\n<div>Medical Director, BIOTOPE CLINIC<\/div>\n<div>Last medically reviewed: 2026-09-10<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"Hyaluronidase in Tokyo explained: how human and animal-derived enzymes dissolve HA filler, realistic timelines, costs and risks. Message us in English today.","protected":false},"author":4,"featured_media":11841,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20,21],"tags":[906,907,908,438,275,26,33],"class_list":["post-11842","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cosmetic-treatments","category-skin-dermatology","tag-hyaluronidase","tag-filler-dissolving","tag-ha-filler-removal","tag-injectables","tag-facial-aesthetics","tag-tokyo-clinic","tag-hyaluronic-acid-filler"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts\/11842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/comments?post=11842"}],"version-history":[{"count":1,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts\/11842\/revisions"}],"predecessor-version":[{"id":11883,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts\/11842\/revisions\/11883"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/media\/11841"}],"wp:attachment":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/media?parent=11842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/categories?post=11842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/tags?post=11842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}