{"id":11874,"date":"2026-09-23T11:27:50","date_gmt":"2026-09-23T02:27:50","guid":{"rendered":"https:\/\/kojihifu.com\/english\/?p=11874"},"modified":"2026-09-23T11:27:51","modified_gmt":"2026-09-23T02:27:51","slug":"how-long-hyaluronidase-dissolves-filler","status":"publish","type":"post","link":"https:\/\/kojihifu.com\/english\/how-long-hyaluronidase-dissolves-filler\/","title":{"rendered":"How Long Does Hyaluronidase Take to Dissolve HA Filler?"},"content":{"rendered":"<p><script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"MedicalWebPage\",\"@id\":\"https:\/\/kojihifu.com\/english\/how-long-hyaluronidase-dissolves-filler\/#webpage\",\"url\":\"https:\/\/kojihifu.com\/english\/how-long-hyaluronidase-dissolves-filler\/\",\"name\":\"How Long Does Hyaluronidase Take to Dissolve HA Filler?\",\"inLanguage\":\"en\",\"isPartOf\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#website\"},\"about\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#clinic-biotope\"},\"reviewedBy\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#physician-karibe\"},\"lastReviewed\":\"2026-09-10\"},{\"@type\":[\"Article\",\"MedicalWebPage\"],\"@id\":\"https:\/\/kojihifu.com\/english\/how-long-hyaluronidase-dissolves-filler\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/kojihifu.com\/english\/how-long-hyaluronidase-dissolves-filler\/#webpage\"},\"headline\":\"How Long Does Hyaluronidase Take to Dissolve HA Filler?\",\"url\":\"https:\/\/kojihifu.com\/english\/how-long-hyaluronidase-dissolves-filler\/\",\"inLanguage\":\"en\",\"author\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#physician-karibe\"},\"reviewedBy\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#physician-karibe\"},\"publisher\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#organization\"},\"mainEntityOfPage\":{\"@id\":\"https:\/\/kojihifu.com\/english\/how-long-hyaluronidase-dissolves-filler\/#webpage\"},\"description\":\"How long does hyaluronidase take to dissolve HA filler? Onset in minutes, most change within 24 hours, plus cost and aftercare in Tokyo. Book a consult.\",\"datePublished\":\"2026-09-10\",\"dateModified\":\"2026-09-10\",\"lastReviewed\":\"2026-09-10\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/kojihifu.com\/english\/how-long-hyaluronidase-dissolves-filler\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/kojihifu.com\/english\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Skin & Dermatology\",\"item\":\"https:\/\/kojihifu.com\/english\/column\/skin-dermatology\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"How Long Does Hyaluronidase Take to Dissolve HA Filler?\",\"item\":\"https:\/\/kojihifu.com\/english\/how-long-hyaluronidase-dissolves-filler\/\"}]}]}<\/script><br \/>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"Will I see a difference the same day?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Usually yes, at least partially \u2014 biphasic fillers can dissolve substantially within 1\u20132 hours. However, swelling from the injection can mask the change, so judge the result after a few days rather than in the mirror on the way home.\"}}, {\"@type\": \"Question\", \"name\": \"How soon can I have new filler injected?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Guidance commonly cited is a minimum of 14 days, so that dissolution is complete and the tissue has settled. Many Japanese practitioners prefer two weeks to a month, particularly after larger-volume dissolution.\"}}, {\"@type\": \"Question\", \"name\": \"Can hyaluronidase dissolve filler injected years ago?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Yes, if the product was hyaluronic acid \u2014 HA remains susceptible to the enzyme regardless of how long it has been in place. Older, heavily cross-linked volumising gels may simply need more enzyme or more than one session.\"}}, {\"@type\": \"Question\", \"name\": \"Is an allergy test necessary?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Practice varies, and it is a point to discuss at consultation. What matters most is disclosing any history of hypersensitivity to hyaluronidase, insect sting reactions or other significant allergies before treatment.\"}}]}<\/script><\/p>\n<h2>How Long Does Hyaluronidase Take to Dissolve HA Filler?<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"How long does hyaluronidase take to dissolve HA fi \u2014 How Long Does Hyaluronidase Take to Dissolve HA Filler\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_7581583_1789011002.webp\" alt=\"How long does hyaluronidase take to dissolve HA fi \u2014 How Long Does Hyaluronidase Take to Dissolve HA Filler\" \/><\/figure>\n<p>If you are unhappy with a<strong> Hyaluronic acid (HA) filler result<\/strong> \u2014 a lump in the lips, an over-filled tear trough, or a cheek that looks heavier than you wanted \u2014 the first question is almost always about time. Waiting weeks for a correction while going to work or meeting clients is genuinely stressful, and the internet gives wildly inconsistent answers.<\/p>\n<p>The short answer: hyaluronidase begins breaking down HA filler within minutes to about an hour, most of the visible change happens within the first 24 hours, and the final result settles over roughly one to two weeks. How fast depends heavily on which filler was used.<\/p>\n<p><strong>What you&#8217;ll learn in this article:<\/strong><\/p>\n<ul>\n<li>The realistic hour-by-hour and day-by-day dissolution timeline, and why it varies<\/li>\n<li>Why some fillers need far more hyaluronidase than others, with figures from recent studies<\/li>\n<li>Current cost at our clinic group in Tokyo, plus downtime and aftercare<\/li>\n<li>Two common misconceptions that lead people to expect the wrong result<\/li>\n<li>Who is a good candidate, and who should avoid the treatment<\/li>\n<\/ul>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>What Is Hyaluronidase and How Does It Work?<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"How long does hyaluronidase take to dissolve HA fi \u2014 What Is Hyaluronidase and How Does It Work\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_4586709_1789011003.webp\" alt=\"How long does hyaluronidase take to dissolve HA fi \u2014 What Is Hyaluronidase and How Does It Work\" \/><\/figure>\n<p><strong>Hyaluronidase<\/strong> is an enzyme that cuts the long chains of hyaluronic acid into small fragments. Those fragments are then cleared by the body&#8217;s normal metabolic pathways, which is why the filler does not need to be physically extracted.<\/p>\n<p>Injectable HA fillers are chemically cross-linked \u2014 <strong>the HA chains<\/strong> are tied together to make a gel that resists breakdown. Hyaluronidase works by getting into the spaces within that gel and cleaving the chains from the inside out, so anything that slows the enzyme&#8217;s access to the gel also slows the result.<\/p>\n<p>It is worth understanding the regulatory picture. In the United States, the FDA-approved indications for recombinant human hyaluronidase (Hylenex, prescribing information revised November 2024) are subcutaneous fluid administration, increasing the dispersion and absorption of other injected drugs, and subcutaneous urography \u2014 dissolving cosmetic filler is not among them.<\/p>\n<p>Using it to reverse filler is therefore an off-label application internationally, supported by a substantial published clinical literature rather than by a label indication. Approval status in Japan is separate from US approval and from insurance coverage; ask your physician which product is being used and on what basis before you consent.<\/p>\n<h2>The Dissolution Timeline, Hour by Hour<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"How long does hyaluronidase take to dissolve HA fi \u2014 The Dissolution Timeline, Hour by Hour\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_16131210_1789011005.webp\" alt=\"How long does hyaluronidase take to dissolve HA fi \u2014 The Dissolution Timeline, Hour by Hour\" \/><\/figure>\n<h3>The first 5 minutes to 1 hour<\/h3>\n<p><strong>A 2025 review<\/strong> in <em>Plastic and Reconstructive Surgery Global Open<\/em> describes a clear split by filler architecture. With biphasic fillers (particle-type gels with looser spaces between particles), diluted hyaluronidase integrates with the filler &#8220;almost immediately, often within approximately 5 minutes.&#8221;<\/p>\n<p>Monophasic fillers \u2014 smooth, more heavily cross-linked gels \u2014 behave differently. The same review notes it takes approximately an hour after injection before the solution begins permeating the gel&#8217;s tighter internal spaces.<\/p>\n<h3>1 to 24 hours<\/h3>\n<p>This is where most of the visible change happens. Clinical reports indicate biphasic filler masses can dissolve almost completely within 1\u20132 hours, whereas for monophasic gels the process &#8220;can extend up to 24 hours, depending on the specific type.&#8221;<\/p>\n<p>An in vitro study of 22 commercially available HA fillers published in <em>Ophthalmic Plastic and Reconstructive Surgery<\/em> in 2025 photographed the gels at 15 minutes, 30 minutes, 1, 2, 3 and 6 hours, which reflects how the enzyme&#8217;s effect unfolds over hours rather than seconds.<\/p>\n<h3>Days 2 to 14<\/h3>\n<p><strong>Enzymatic degradation<\/strong> continues well past the first day. An experimental study published in <em>Aesthetic Surgery Journal Open Forum<\/em> in 2025 measured degradation at 1, 6, 24 and 48 hours and found it still increasing at the 48-hour mark.<\/p>\n<p>Clinically, the tissue also has to settle. Guidance from the Cleveland Clinic states that some results are visible immediately but &#8220;it can take up to two weeks to see the full results,&#8221; and recommends waiting at least 14 days before re-injecting filler.<\/p>\n<table style=\"border-collapse: collapse; width: 100%; margin: 20px 0; font-size: 0.95em; border: 1px solid #ccc;\">\n<thead>\n<tr>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Filler type<\/th>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Enzyme starts acting<\/th>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Bulk of visible change<\/th>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Typical sessions<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Biphasic (particle-type gels)<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Around 5 minutes<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">1\u20132 hours<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Often 1<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Monophasic (smooth cohesive gels)<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Around 1 hour<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Up to 24 hours<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">1\u20132<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Highly cross-linked volumising gels<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Around 1 hour, slower penetration<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">24 hours, with further settling over 1\u20132 weeks<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Frequently more than 1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>What People Often Get Wrong About Dissolving Filler<\/h2>\n<h3>Misconception 1: &#8220;One injection removes everything&#8221;<\/h3>\n<p>Fillers differ enormously in how much enzyme they need. In the 22-filler in vitro study, the least resistant products (Restylane-L and Restylane Lyft) dissolved with as little as 2.5 units per 0.2 mL aliquot, while the most resistant (including RHA 2, 3 and 4, Belotero Volume and Juv\u00e9derm Volux) required 120 units or more \u2014 a range of 2.5 to 140 units across the panel.<\/p>\n<p>Reviews of clinical practice suggest roughly 600\u2013750 units of hyaluronidase per millilitre of filler for elective dissolution, and the Cleveland Clinic notes that lip filler can usually be dissolved in one to two visits, with larger volumes or nodules sometimes needing more. In Dr. Karibe&#8217;s clinical experience at BIOTOPE CLINIC, patients who do not know which product was originally injected \u2014 common when the filler was placed abroad \u2014 are the ones most likely to need a second session.<\/p>\n<h3>Misconception 2: &#8220;It only touches the filler&#8221;<\/h3>\n<p>Hyaluronidase is not selective. It also degrades the hyaluronic acid naturally present in your tissue, which is why the treated area can temporarily look flatter, finer-lined or slightly hollow before it recovers. The FDA prescribing information for recombinant hyaluronidase notes that restoration of the tissue&#8217;s normal permeability barrier is incomplete at 24 hours and complete at 48 hours, which gives a sense of how transient the effect on native tissue is.<\/p>\n<h2>Cost in Tokyo<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"How long does hyaluronidase take to dissolve HA fi \u2014 Cost in Tokyo\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_7581577_1789011006.webp\" alt=\"How long does hyaluronidase take to dissolve HA fi \u2014 Cost in Tokyo\" \/><\/figure>\n<p>Our clinic group publishes a single tax-inclusive price list covering both locations (effective 1 October 2023).<\/p>\n<p>Hyaluronidase is listed at 11,000 yen per 0.1 mL for filler originally injected at our clinics, and 22,000 yen per 0.1 mL for filler injected elsewhere \u2014 the higher figure reflects the additional assessment involved when the product and injection depth are unknown.<\/p>\n<p>Consultation is listed at 3,300 yen (initial or follow-up), with an additional 2,200 yen for a cosmetic surgery consultation specifically with Dr. Karibe. Anaesthesia, pre-treatment blood work and medications are charged separately. Because the total depends on how much filler is present and how resistant it proves to be, please see the clinic&#8217;s official price page for current figures. For an accurate quote, please book a consultation.<\/p>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>What to Expect: Downtime, Candidacy and Aftercare<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"How long does hyaluronidase take to dissolve HA fi \u2014 What to Expect: Downtime, Candidacy and Aftercare\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_3985311_1789011007.webp\" alt=\"How long does hyaluronidase take to dissolve HA fi \u2014 What to Expect: Downtime, Candidacy and Aftercare\" \/><\/figure>\n<h3>On the day<\/h3>\n<p>The injection itself is brief \u2014 the Cleveland Clinic describes a lip-filler dissolution appointment as taking roughly 10 to 15 minutes. Most patients return to normal activity the same day.<\/p>\n<p>Expect swelling, tenderness, redness and possible bruising. Reported recovery for dissolving lip filler is minor bruising and swelling lasting up to about a week, so it is sensible to leave a clear week before a wedding, a photoshoot or an important presentation.<\/p>\n<h3>Who is a good candidate<\/h3>\n<p>Good candidates include people with over-filled or asymmetric results, palpable lumps or nodules, filler migration, Tyndall effect (a bluish-grey tint from HA placed too superficially), and those needing correction before a planned revision. Hyaluronidase is also the emergency treatment for vascular occlusion, where filler compromises blood supply \u2014 published protocols describe high-dose pulsed regimens of 450\u20131500 units repeated approximately every 30\u201360 minutes, which is why any sudden blanching, severe pain or visual change after filler must be treated as urgent.<\/p>\n<h3>Who should avoid it<\/h3>\n<p>Hyaluronidase is contraindicated in anyone with known hypersensitivity to hyaluronidase or the product&#8217;s excipients. Severe allergic reactions including anaphylaxis have been reported, though rarely, so tell your physician about any history of bee or wasp sting reactions and about all allergies. It also cannot reverse non-HA fillers such as calcium hydroxylapatite, poly-L-lactic acid or permanent silicone \u2014 a firm lump does not automatically mean HA.<\/p>\n<h2>Where to Get Filler Dissolution in Tokyo<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"How long does hyaluronidase take to dissolve HA fi \u2014 Where to Get Filler Dissolution in Tokyo\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_27925589_1789011009.webp\" alt=\"How long does hyaluronidase take to dissolve HA fi \u2014 Where to Get Filler Dissolution in Tokyo\" \/><\/figure>\n<p>Within our clinic group, both BIOTOPE CLINIC (Shirokanedai, Minato-ku) and Kojimachi Dermatology &amp; Plastic Surgery Clinic (Ichigaya, Chiyoda-ku) offer English-language consultation with Dr. Jun Karibe&#8217;s team. Hyaluronidase for dissolving HA filler is handled at BIOTOPE CLINIC in Shirokanedai, where Dr. Karibe personally consults. Bookings and enquiries in English: LINE or WhatsApp.<\/p>\n<p>The two clinics are sister sites under the same medical group. Kojimachi focuses on insurance-covered general dermatology and general plastic surgery; BIOTOPE covers cosmetic dermatology, injectables and men&#8217;s health. If you plan to re-treat after dissolution, hyaluronic acid filler and Botox are both available at BIOTOPE CLINIC in Shirokanedai \u2014 feel free to ask about the right interval during your consultation.<\/p>\n<h2>Frequently Asked Questions<\/h2>\n<dl class=\"kj-faq\">\n<dt>Q. Will I see a difference the same day?<\/dt>\n<dd>Usually yes, at least partially \u2014 biphasic fillers can dissolve substantially within 1\u20132 hours. However, swelling from the injection can mask the change, so judge the result after a few days rather than in the mirror on the way home.<\/dd>\n<dd><\/dd>\n<dt>Q. How soon can I have new filler injected?<\/dt>\n<dd>Guidance commonly cited is a minimum of 14 days, so that dissolution is complete and the tissue has settled. Many Japanese practitioners prefer two weeks to a month, particularly after larger-volume dissolution.<\/dd>\n<dd><\/dd>\n<dt>Q. Can hyaluronidase dissolve filler injected years ago?<\/dt>\n<dd>Yes, if the product was hyaluronic acid \u2014 HA remains susceptible to the enzyme regardless of how long it has been in place. Older, heavily cross-linked volumising gels may simply need more enzyme or more than one session.<\/dd>\n<dd><\/dd>\n<dt>Q. Is an allergy test necessary?<\/dt>\n<dd>Practice varies, and it is a point to discuss at consultation. What matters most is disclosing any history of hypersensitivity to hyaluronidase, insect sting reactions or other significant allergies before treatment.<\/dd>\n<\/dl>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>Summary<\/h2>\n<p><strong>Hyaluronidase<\/strong> starts working within about 5 minutes to 1 hour depending on the filler&#8217;s structure, delivers most of its visible effect within 1 to 24 hours, and reaches a final settled result over roughly one to two weeks. Studies suggest the amount of enzyme required varies more than tenfold between products, which is the main reason timelines differ between individuals.<\/p>\n<p>Plan for around a week of possible swelling and bruising, expect that one to two sessions may be needed, and be aware that native tissue hyaluronic acid is temporarily affected as well. Results are not guaranteed and depend on the filler involved, its volume and its depth.<\/p>\n<p>If you have questions about how long hyaluronidase takes to dissolve HA filler, both BIOTOPE CLINIC (Shirokanedai, Minato-ku) and Kojimachi Dermatology &amp; Plastic Surgery Clinic (Ichigaya, Chiyoda-ku) offer English-language consultation with Dr. Karibe and his team. Hyaluronidase treatment is primarily handled at <strong>BIOTOPE CLINIC<\/strong> in Shirokanedai. English enquiries: LINE or WhatsApp.<\/p>\n<div class=\"kjmc-en-booking-box\" style=\"background: linear-gradient(135deg,#f1faf3 0%,#e6f3ea 100%); border-radius: 14px; padding: 32px 24px; margin: 36px 0 24px; border: 1px solid #c5dccd; text-align: center;\">\n<h3 style=\"margin: 0 0 8px; color: #3a6e3a; border: none; padding: 0; font-size: 1.3em;\">24\/7 Consultation &amp; Booking<\/h3>\n<div style=\"width: 48px; height: 2px; background: #3a6e3a; margin: 0 auto 22px;\"><\/div>\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 1.1em; font-weight: bold;\">Book a Consultation or Treatment<\/p>\n<p style=\"margin: 0 0 24px; color: #2c4a35; line-height: 1.75;\">Our English-speaking team responds via LINE or WhatsApp \u2014 usually the same day.<\/p>\n<p style=\"margin: 0 0 10px; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; justify-content: center; gap: 10px; background: #06C755; color: #fff; padding: 14px 32px; border-radius: 10px; text-decoration: none; font-weight: bold; font-size: 1.02em; box-shadow: 0 2px 8px rgba(6,199,85,0.25); min-width: 240px; white-space: nowrap;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; justify-content: center; gap: 10px; background: #25D366; color: #fff; padding: 14px 32px; border-radius: 10px; text-decoration: none; font-weight: bold; font-size: 1.02em; box-shadow: 0 2px 8px rgba(37,211,102,0.25); min-width: 240px; white-space: nowrap;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>References<\/h2>\n<ol>\n<li>Yi KH, Wan J, Yoon SE. Considerations for Proper Use of Hyaluronidase in the Management of Hyaluronic Acid Fillers. Plastic and Reconstructive Surgery Global Open. 2025;13(3):e6566.<\/li>\n<li>Sudharshan R, Davuluru SS, Shen AJ, et al. Identifying Minimum Single Dose of Recombinant Human Hyaluronidase for In Vitro Dissolution of Twenty-Two Hyaluronic Acid Fillers. Ophthalmic Plastic and Reconstructive Surgery. 2025;41(6):657\u2013663.<\/li>\n<li>Oliveira J, Santos V, Marques J, Silva N, Mata A, Brito da Cruz M. Effectiveness of Hyaluronidase on Hyaluronic Acid Degradation: An Experimental Study. Aesthetic Surgery Journal Open Forum. 2025;7:ojaf108.<\/li>\n<li>Hylenex Recombinant (hyaluronidase human injection) Prescribing Information, revised November 2024. US Food and Drug Administration. <a href=\"https:\/\/www.fda.gov\/\">https:\/\/www.fda.gov\/<\/a><\/li>\n<li>Cleveland Clinic. Dissolving Lip Filler: Treatment Overview. Cleveland Clinic Health Library. 2026.<\/li>\n<\/ol>\n<h2>Related Articles<\/h2>\n<p>You may also find these articles useful.<\/p>\n<ul>\n<li><a href=\"https:\/\/kojihifu.com\/english\/ha-filler-tokyo-downtime-stay-flying\/\" target=\"_blank\" rel=\"noopener\">How Long Should You Stay in Tokyo for HA Filler? Downtime, Bruising &amp; Flying Guide<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/dermal-filler-tokyo-price-guide-2\/\" target=\"_blank\" rel=\"noopener\">Dermal Filler Tokyo: Price Guide &amp; Clinic Selection Tips<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/under-eye-filler-tokyo-risks-benefits-3\/\" target=\"_blank\" rel=\"noopener\">Under Eye Filler Tokyo: Risks, Benefits &amp; Costs<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/lip-filler-tokyo-cost-guide-3\/\" target=\"_blank\" rel=\"noopener\">Lip Filler Tokyo: Cost, Treatment &amp; Clinic Guide<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/volnewmer-jawline-cheeks-tokyo\/\" target=\"_blank\" rel=\"noopener\">Filler for Jawline and Cheeks Tokyo<\/a><\/li>\n<\/ul>\n<div style=\"margin: 2.5em 0 1em; padding: 1.5em; border: 1px solid #d5d5d5; border-radius: 10px; background: #fafafa; font-size: .9em;\">\n<p style=\"font-size: .72em; font-weight: bold; color: #888; margin: 0 0 1.2em; letter-spacing: .08em;\">SUPERVISED BY<\/p>\n<div style=\"display: flex; align-items: flex-start; gap: 1.2em; flex-wrap: wrap;\">\n<div style=\"flex-shrink: 0; text-align: center; min-width: 110px;\"><img decoding=\"async\" style=\"width: 100px; height: 100px; border-radius: 50%; object-fit: cover; object-position: top center; display: block; margin: 0 auto; border: 3px solid #e0e0e0;\" src=\"https:\/\/kojihifu.com\/hon\/wp-content\/uploads\/2022\/01\/photo-karibejun-400-3_re-300x300.jpg\" alt=\"Dr. Jun Karibe MD \u2014 Board-certified Plastic Surgeon, Director of Kojimachi Dermatology &amp; Plastic Surgery Clinic\" \/><\/p>\n<p style=\"margin: .6em 0 .1em; font-weight: bold; font-size: .95em; color: #222;\">Dr. Jun Karibe<\/p>\n<p style=\"margin: 0 0 .1em; font-size: .75em; color: #999;\">MD<\/p>\n<p style=\"margin: 0; font-size: .75em; color: #555; font-weight: bold;\">Director<\/p>\n<\/div>\n<div style=\"flex: 1; min-width: 200px;\">\n<div style=\"margin-bottom: .75em; background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Education &amp; Career<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Juntendo University School of Medicine<\/div>\n<div>Department of Plastic Surgery, University of Tokyo Hospital<\/div>\n<div>Assistant Professor, Plastic &amp; Cosmetic Surgery, Saitama Medical University<\/div>\n<div>Assistant Professor &amp; Chief Resident, Yamanashi University Hospital<\/div>\n<div>2019: Founded Kojimachi Dermatology &amp; Plastic Surgery Clinic (Ichigaya, Tokyo)<\/div>\n<div>2021: Founded BIOTOPE CLINIC Shirokanedai (Minato-ku, Tokyo)<\/div>\n<\/div>\n<\/div>\n<div style=\"margin-bottom: .75em; background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Certifications<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Board-certified Plastic Surgeon \u2014 Japan Society of Plastic and Reconstructive Surgery<\/div>\n<div>Specialist \u2014 Japan Society of Anti-Aging Medicine<\/div>\n<div>Certified Industrial Physician \u2014 Japan Medical Association<\/div>\n<div>Allergan VST-certified Injector (Botox &amp; Hyaluronic Acid)<\/div>\n<\/div>\n<\/div>\n<div style=\"background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Awards<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Best Presentation Award \u2014 Dept. of Plastic Surgery, University of Tokyo (2016)<\/div>\n<div>Excellence Award \u2014 Japan Society of Plastic and Reconstructive Surgery (2018)<\/div>\n<div>Featured Presentation \u2014 ASPS Annual Scientific Meeting, USA (2018)<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"margin-top: 1em; padding-top: .75em; border-top: 1px solid #e8e8e8; display: flex; flex-wrap: wrap; align-items: center; gap: .5em;\"><a style=\"display: inline-block; background: #e1306c; color: #fff; padding: .4em .9em; border-radius: 4px; text-decoration: none; font-size: .8em; font-weight: bold;\" href=\"https:\/\/www.instagram.com\/dr.jun_\/\" target=\"_blank\" rel=\"noopener noreferrer\">Instagram<\/a><\/p>\n<div style=\"margin-top: 1em; padding-top: .75em; border-top: 1px dashed #d5d5d5; font-size: .78em; color: #555; line-height: 1.7;\">\n<p style=\"margin: 0 0 .3em; font-size: .72em; font-weight: bold; color: #888; letter-spacing: .08em;\">MEDICAL REVIEW<\/p>\n<div><strong>Jun Karibe, MD<\/strong> \u2014 Board-certified Plastic Surgeon \u2014 Japan Society of Plastic and Reconstructive Surgery<\/div>\n<div>Medical Director, BIOTOPE CLINIC<\/div>\n<div>Last medically reviewed: 2026-09-10<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"How long does hyaluronidase take to dissolve HA filler? Onset in minutes, most change within 24 hours, plus cost and aftercare in Tokyo. Book a consult.","protected":false},"author":4,"featured_media":11873,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20,21],"tags":[907,913,917,558,26,32],"class_list":["post-11874","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cosmetic-treatments","category-skin-dermatology","tag-filler-dissolving","tag-ha-filler","tag-tear-trough","tag-dermal-fillers","tag-tokyo-clinic","tag-lip-filler"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts\/11874","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/comments?post=11874"}],"version-history":[{"count":1,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts\/11874\/revisions"}],"predecessor-version":[{"id":12486,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts\/11874\/revisions\/12486"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/media\/11873"}],"wp:attachment":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/media?parent=11874"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/categories?post=11874"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/tags?post=11874"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}