{"id":12213,"date":"2026-09-22T18:11:20","date_gmt":"2026-09-22T09:11:20","guid":{"rendered":"https:\/\/kojihifu.com\/english\/?p=12213"},"modified":"2026-09-22T18:11:21","modified_gmt":"2026-09-22T09:11:21","slug":"exosome-therapy-tokyo-skin-rejuvenation-4","status":"publish","type":"post","link":"https:\/\/kojihifu.com\/english\/exosome-therapy-tokyo-skin-rejuvenation-4\/","title":{"rendered":"Exosome Therapy Tokyo: Skin Rejuvenation &#038; Anti-Aging Guide"},"content":{"rendered":"<p><script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"MedicalWebPage\",\"@id\":\"https:\/\/kojihifu.com\/english\/exosome-therapy-tokyo-skin-rejuvenation\/#webpage\",\"url\":\"https:\/\/kojihifu.com\/english\/exosome-therapy-tokyo-skin-rejuvenation\/\",\"name\":\"Exosome Therapy Tokyo: Skin Rejuvenation & Anti-Aging Guide\",\"inLanguage\":\"en\",\"isPartOf\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#website\"},\"about\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#clinic-biotope\"},\"reviewedBy\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#physician-karibe\"},\"lastReviewed\":\"2026-09-15\"},{\"@type\":[\"Article\",\"MedicalWebPage\"],\"@id\":\"https:\/\/kojihifu.com\/english\/exosome-therapy-tokyo-skin-rejuvenation\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/kojihifu.com\/english\/exosome-therapy-tokyo-skin-rejuvenation\/#webpage\"},\"headline\":\"Exosome Therapy Tokyo: Skin Rejuvenation & Anti-Aging Guide\",\"url\":\"https:\/\/kojihifu.com\/english\/exosome-therapy-tokyo-skin-rejuvenation\/\",\"inLanguage\":\"en\",\"author\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#physician-karibe\"},\"reviewedBy\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#physician-karibe\"},\"publisher\":{\"@id\":\"https:\/\/kojihifu.com\/english\/#organization\"},\"mainEntityOfPage\":{\"@id\":\"https:\/\/kojihifu.com\/english\/exosome-therapy-tokyo-skin-rejuvenation\/#webpage\"},\"description\":\"Discover exosome therapy in Tokyo for skin rejuvenation and anti-aging \u2014 how it works, realistic results versus PRP and HIFU, and what to expect. Learn more.\",\"datePublished\":\"2026-09-15\",\"dateModified\":\"2026-09-15\",\"lastReviewed\":\"2026-09-15\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/kojihifu.com\/english\/exosome-therapy-tokyo-skin-rejuvenation\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/kojihifu.com\/english\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Skin & Dermatology\",\"item\":\"https:\/\/kojihifu.com\/english\/column\/skin-dermatology\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Exosome Therapy Tokyo: Skin Rejuvenation & Anti-Aging Guide\",\"item\":\"https:\/\/kojihifu.com\/english\/exosome-therapy-tokyo-skin-rejuvenation\/\"}]}]}<\/script><br \/>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"Is exosome therapy the same as PRP?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"No. PRP uses concentrated platelets and growth factors from your own blood, while exosome therapy uses vesicles typically derived from cultured stem cells, administered without any living cells. Both aim to support collagen production, but the source material and regulatory considerations differ.\"}}, {\"@type\": \"Question\", \"name\": \"How many sessions are usually needed?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"This varies by individual goals and the delivery method used. Your consultation with Dr. Karibe's team will outline a plan based on your skin assessment \u2014 for an accurate recommendation, please book a consultation.\"}}, {\"@type\": \"Question\", \"name\": \"Is exosome therapy covered by insurance in Japan?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"No. It is offered as self-pay (\u81ea\u7531\u8a3a\u7642) cosmetic and regenerative medicine, not as insurance-covered treatment for a diagnosed medical condition.\"}}, {\"@type\": \"Question\", \"name\": \"Are there risks I should know about?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Reviewed studies report a favourable short-term safety profile with no significant adverse reactions to date, but the overall evidence base remains limited, with small sample sizes and inconsistent product standardisation across the industry. Discuss your medical history, including any cancer history, with your doctor beforehand.\"}}]}<\/script><\/p>\n<h2>What Is Exosome Therapy?<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Exosome therapy Tokyo: skin rejuvenation and anti- \u2014 What Is Exosome Therapy\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_20377674_1789428428.webp\" alt=\"Exosome therapy Tokyo: skin rejuvenation and anti- \u2014 What Is Exosome Therapy\" \/><\/figure>\n<p><strong>Exosomes <\/strong>are tiny, naturally occurring vesicles \u2014 roughly 30 to 150 nanometres across \u2014 that cells release to communicate with one another. They carry proteins, growth factors, and genetic material such as microRNA, which can influence the behaviour of neighbouring cells, including skin fibroblasts.<\/p>\n<p>In aesthetic medicine, exosomes are typically derived from cultured stem cells and are administered without any living cells present. The treatment is marketed for skin texture, tone, and firmness, and is often positioned as a complement to procedures such as microneedling, HIFU, or laser resurfacing rather than a replacement for them.<\/p>\n<p>It is worth stating clearly: exosome therapy is not the same as stem cell therapy. Exosomes are cell-derived particles, not living cells, and this distinction matters for both how the treatment works and how it is currently regulated in Japan, which we cover below.<\/p>\n<h2>How Exosome Therapy Works for Skin Rejuvenation<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Exosome therapy Tokyo: skin rejuvenation and anti- \u2014 How Exosome Therapy Works for Skin Rejuvenation\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_35899861_1789428429.webp\" alt=\"Exosome therapy Tokyo: skin rejuvenation and anti- \u2014 How Exosome Therapy Works for Skin Rejuvenation\" \/><\/figure>\n<p>Once introduced into the skin \u2014 by injection, microneedling, or topical application after a device-assisted procedure \u2014 exosomes are thought to deliver growth factors and signalling molecules to fibroblasts, the cells responsible for producing collagen and elastin.<\/p>\n<p>Research reviewed in the <em>Journal of Cosmetic Dermatology<\/em> suggests this signalling can reduce the activity of enzymes (matrix metalloproteinases) that break down collagen, while supporting new collagen and elastin synthesis.<\/p>\n<p>Other proposed mechanisms include modulating melanin production, which is why exosomes are also studied for pigmentation, and supporting wound-healing pathways relevant to scarring. At<strong> BIOTOPE CLINIC<\/strong> in Shirokanedai, we frequently see patients who are combining exosome therapy with an existing HIFU or Morpheus8 RF microneedling programme, using exosomes as a supportive step rather than a stand-alone transformation.<\/p>\n<h2>Expected Results<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Exosome therapy Tokyo: skin rejuvenation and anti- \u2014 Expected Results\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_9775174_1789428430.webp\" alt=\"Exosome therapy Tokyo: skin rejuvenation and anti- \u2014 Expected Results\" \/><\/figure>\n<p>Clinical reports indicate measurable but modest improvements. A 2026 systematic review and meta-analysis in <em>Aesthetic Surgery Journal<\/em>, which pooled data from 39 human clinical trials, found an average facial wrinkle reduction of 20.2% (95% CI, 15.3%\u201325.2%; P &lt; .001), alongside improvements of 14.7% to 23.4% in pigmentation, elasticity, texture, and redness across the studies reviewed.<\/p>\n<p>These figures describe group averages across a mixed evidence base, not a guaranteed individual outcome.<\/p>\n<p>A separate 2025 review in the <em>International Journal of Molecular Sciences<\/em> cautions that many of the underlying studies lack standardised production methods and long-term follow-up, so results can vary between products, clinics, and patients.<\/p>\n<table style=\"border-collapse: collapse; width: 100%; margin: 20px 0; font-size: 0.95em; border: 1px solid #ccc;\">\n<thead>\n<tr>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Approach<\/th>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">How It Works<\/th>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Typical Downtime<\/th>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Best Suited For<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Exosome therapy<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Delivers growth factors\/signalling molecules to support collagen production<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Minimal to none (mild redness possible)<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Dullness, fine lines, uneven texture; often paired with other treatments<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">PRP (platelet-rich plasma)<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Concentrates the patient&#8217;s own platelets and growth factors<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">1\u20133 days of mild swelling\/bruising<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Patients preferring an autologous (self-derived) approach<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">HIFU \/ Morpheus8 RF microneedling<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Uses focused ultrasound or radiofrequency to stimulate deeper collagen remodelling<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">A few days of redness or mild swelling<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Skin laxity and contouring, often combined with exosomes<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Cost of Exosome Therapy in Tokyo<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Exosome therapy Tokyo: skin rejuvenation and anti- \u2014 Cost of Exosome Therapy in Tokyo\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_8102129_1789428431.webp\" alt=\"Exosome therapy Tokyo: skin rejuvenation and anti- \u2014 Cost of Exosome Therapy in Tokyo\" \/><\/figure>\n<p><strong>Exosome therapy<\/strong> in Japan is a self-pay (\u81ea\u7531\u8a3a\u7642) treatment; it is not covered by Japanese national health insurance, since it is classified as cosmetic and regenerative medicine rather than treatment for a diagnosed disease. Pricing depends on the delivery method, the number of sessions, and the exosome product used.<\/p>\n<p>At <strong>BIOTOPE CLINIC<\/strong>, exosome treatment is currently listed at \u00a5660,000 for an intravenous infusion, or \u00a5660,000 per site for local (targeted) injection. Please see the clinic&#8217;s official price page or contact us for a current quote, as pricing structures can change. For an accurate quote, please book a consultation.<\/p>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>What to Expect: Before, During and After Treatment<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Exosome therapy Tokyo: skin rejuvenation and anti- \u2014 What to Expect: Before, During and After Treatment\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_17891765_1789428432.webp\" alt=\"Exosome therapy Tokyo: skin rejuvenation and anti- \u2014 What to Expect: Before, During and After Treatment\" \/><\/figure>\n<h3>Before<\/h3>\n<p>Your consultation will cover your skin concerns, medical history, and whether exosome therapy suits your goals \u2014 or whether another treatment, or a combination, would serve you better. Dr. Karibe&#8217;s team will also explain the product&#8217;s source and handling, since quality control varies between suppliers.<\/p>\n<h3>During<\/h3>\n<p>Depending on the delivery method, the session may involve an IV infusion lasting roughly 30\u201360 minutes, or a series of fine injections into the treatment area, sometimes paired with microneedling to improve penetration. Most sessions do not require anaesthesia beyond a topical numbing cream.<\/p>\n<h3>After<\/h3>\n<p>Downtime is typically minimal \u2014 mild redness or small injection marks that resolve within a day or two are common. Visible changes in skin quality tend to build gradually over several weeks as collagen remodelling occurs, rather than appearing immediately.<\/p>\n<h2>Who Is a Good Candidate?<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Exosome therapy Tokyo: skin rejuvenation and anti- \u2014 Who Is a Good Candidate\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/09\/pexels_7321499_1789428433.webp\" alt=\"Exosome therapy Tokyo: skin rejuvenation and anti- \u2014 Who Is a Good Candidate\" \/><\/figure>\n<p><strong>Exosome therapy<\/strong> tends to suit adults with early-to-moderate signs of ageing \u2014 fine lines, dullness, or uneven texture \u2014 who want a low-downtime option, potentially alongside device-based treatments. It may also appeal to patients who prefer to avoid the autologous blood draw required for PRP.<\/p>\n<p>It is not appropriate for everyone. Pregnant or breastfeeding patients, and those with active skin infections in the treatment area, are generally advised against injectable regenerative treatments as a matter of standard clinical caution.<\/p>\n<p>Patients with a personal history of cancer should discuss exosome therapy with their physician beforehand, given that its proposed mechanism involves stimulating cell growth signalling \u2014 an area regulators have specifically flagged as needing scrutiny.<\/p>\n<h2>Common Misconceptions About Exosome Therapy<\/h2>\n<p><strong>&#8220;Exosome therapy is government-approved.&#8221;<\/strong><\/p>\n<p>No exosome-based product has received pharmaceutical marketing approval from Japan&#8217;s regulators, or from the U.S. FDA, for any medical or cosmetic indication. In Japan, exosome and cell-culture-supernatant treatments currently fall outside the scope of the Act on the Safety of<\/p>\n<p>Regenerative Medicine specifically because they do not contain living cells \u2014 though a Ministry of Health, Labour and Welfare working group recommended in 2025 that this gap be closed, and the ministry&#8217;s regenerative medicine evaluation committee opened formal discussion on new rules in July 2026. In practice, this means the treatment is offered as self-pay medicine under general clinical safety guidance, not under a dedicated approval framework \u2014 a distinction worth understanding before booking.<\/p>\n<p><strong>&#8220;Exosomes and stem cells are the same thing.&#8221;<\/strong><\/p>\n<p>They are not. Exosomes are acellular vesicles secreted by cells; they do not divide, replicate, or persist in the body as living cells do. This is precisely why they are often marketed as an &#8220;easier&#8221; option than stem cell therapy, but it does not mean the evidence base or safety profile is equivalent to an approved drug \u2014 the FDA has separately warned that some clinics make unsubstantiated claims about what exosome products can treat or cure.<\/p>\n<h2>Where to Get Exosome Therapy in Tokyo<\/h2>\n<p>Within our clinic group, both <strong>BIOTOPE CLINIC<\/strong> (Shirokanedai, Minato-ku) and<strong> Kojimachi Dermatology &amp; Plastic Surgery Clinic<\/strong> (Ichigaya, Chiyoda-ku) offer English-language consultation with Dr. Jun Karibe&#8217;s team. Exosome therapy, along with related regenerative and cosmetic dermatology treatments, is handled at <strong>BIOTOPE CLINIC<\/strong> in Shirokanedai. <strong>Kojimachi Dermatology &amp; Plastic Surgery Clinic<\/strong> remains the group&#8217;s main office for insurance-covered general dermatology and general\/aesthetic plastic surgery. Bookings and enquiries in English: LINE or WhatsApp.<\/p>\n<h2>Frequently Asked Questions<\/h2>\n<dl class=\"kj-faq\">\n<dt>Q. Is exosome therapy the same as PRP?<\/dt>\n<dd>No. PRP uses concentrated platelets and growth factors from your own blood, while exosome therapy uses vesicles typically derived from cultured stem cells, administered without any living cells. Both aim to support collagen production, but the source material and regulatory considerations differ.<\/dd>\n<dd><\/dd>\n<dt>Q. How many sessions are usually needed?<\/dt>\n<dd>This varies by individual goals and the delivery method used. Your consultation with Dr. Karibe&#8217;s team will outline a plan based on your skin assessment \u2014 for an accurate recommendation, please book a consultation.<\/dd>\n<dd><\/dd>\n<dt>Q. Is exosome therapy covered by insurance in Japan?<\/dt>\n<dd>No. It is offered as self-pay (\u81ea\u7531\u8a3a\u7642) cosmetic and regenerative medicine, not as insurance-covered treatment for a diagnosed medical condition.<\/dd>\n<dt>Q. Are there risks I should know about?<\/dt>\n<dd>Reviewed studies report a favourable short-term safety profile with no significant adverse reactions to date, but the overall evidence base remains limited, with small sample sizes and inconsistent product standardisation across the industry. Discuss your medical history, including any cancer history, with your doctor beforehand.<\/dd>\n<\/dl>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>Summary<\/h2>\n<p><strong>Exosome therapy<\/strong> is a low-downtime regenerative treatment with growing but still-developing clinical evidence behind it \u2014 studies suggest measurable, moderate improvements in wrinkles, texture, and tone, though results vary and the field lacks standardisation.<\/p>\n<p>In Japan, it is offered as self-pay medicine, sits outside the current scope of the Act on the Safety of Regenerative Medicine, and is the subject of an active 2026 regulatory review. If you have questions about exosome therapy, both <strong>BIOTOPE CLINIC<\/strong> (Shirokanedai, Minato-ku) and Kojimachi Dermatology &amp; Plastic Surgery Clinic (Ichigaya, Chiyoda-ku) offer English-language consultation with Dr. Karibe and his team. Exosome therapy is primarily handled at BIOTOPE CLINIC. English enquiries: LINE or WhatsApp.<\/p>\n<div class=\"kjmc-en-booking-box\" style=\"background: linear-gradient(135deg,#f1faf3 0%,#e6f3ea 100%); border-radius: 14px; padding: 32px 24px; margin: 36px 0 24px; border: 1px solid #c5dccd; text-align: center;\">\n<h3 style=\"margin: 0 0 8px; color: #3a6e3a; border: none; padding: 0; font-size: 1.3em;\">24\/7 Consultation &amp; Booking<\/h3>\n<div style=\"width: 48px; height: 2px; background: #3a6e3a; margin: 0 auto 22px;\"><\/div>\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 1.1em; font-weight: bold;\">Book a Consultation or Treatment<\/p>\n<p style=\"margin: 0 0 24px; color: #2c4a35; line-height: 1.75;\">Our English-speaking team responds via LINE or WhatsApp \u2014 usually the same day.<\/p>\n<p style=\"margin: 0 0 10px; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; justify-content: center; gap: 10px; background: #06C755; color: #fff; padding: 14px 32px; border-radius: 10px; text-decoration: none; font-weight: bold; font-size: 1.02em; box-shadow: 0 2px 8px rgba(6,199,85,0.25); min-width: 240px; white-space: nowrap;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; justify-content: center; gap: 10px; background: #25D366; color: #fff; padding: 14px 32px; border-radius: 10px; text-decoration: none; font-weight: bold; font-size: 1.02em; box-shadow: 0 2px 8px rgba(37,211,102,0.25); min-width: 240px; white-space: nowrap;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>References<\/h2>\n<ol>\n<li>Stack ER, Spongberg C, Braud SC, Stanton WN, Elway M. Clinical Advances in Exosome-Based Therapies for Aesthetic Medicine: A Systematic Review and Meta-analysis of Human Clinical Trials. Aesthetic Surgery Journal. 2026;46(Supplement_1):S13-S25.<\/li>\n<li>Shah H, et al. Exosomes for Aesthetic Dermatology: A Comprehensive Literature Review and Update. Journal of Cosmetic Dermatology. 2025;24(1):e16766.<\/li>\n<li>Domaszewska-Szostek A, Krzy\u017canowska M, Polak A, Puzianowska-Ku\u017anicka M. Effectiveness of Extracellular Vesicle Application in Skin Aging Treatment and Regeneration: Do We Have Enough Evidence from Clinical Trials? International Journal of Molecular Sciences. 2025;26(5):2354.<\/li>\n<li>U.S. Food and Drug Administration. Public Safety Alert Due to Marketing of Unapproved Stem Cell and Exosome Products. 2024.<\/li>\n<li>Ministry of Health, Labour and Welfare (Japan). Administrative notice on the safe implementation of medical technologies using exosomes. July 2024; and related regenerative medicine evaluation committee discussions, 2025\u20132026.<\/li>\n<\/ol>\n<h2>Related Articles<\/h2>\n<p>You may also find these articles useful.<\/p>\n<ul>\n<li><a href=\"https:\/\/kojihifu.com\/english\/regenerative-medicine-tokyo-stem-cells-exosomes\/\" target=\"_blank\" rel=\"noopener\">Stem Cells vs Exosomes vs Supernatant in Tokyo<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/autologous-stem-cell-therapy-tokyo-2\/\" target=\"_blank\" rel=\"noopener\">Autologous Stem Cell Therapy Tokyo: Skin Rejuvenation<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/autologous-stem-cell-therapy-tokyo\/\" target=\"_blank\" rel=\"noopener\">Autologous Cultured Stem Cell Therapy Tokyo<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/anti-aging-treatments-tokyo-expats-2\/\" target=\"_blank\" rel=\"noopener\">Anti-Aging Treatments Tokyo: Complete Guide for Expats<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/nmn-drip-therapy-tokyo-guide-2\/\" target=\"_blank\" rel=\"noopener\">NMN Drip Therapy Tokyo: Anti-Aging IV Treatment Guide<\/a><\/li>\n<\/ul>\n<div style=\"margin: 2.5em 0 1em; padding: 1.5em; border: 1px solid #d5d5d5; border-radius: 10px; background: #fafafa; font-size: .9em;\">\n<p style=\"font-size: .72em; font-weight: bold; color: #888; margin: 0 0 1.2em; letter-spacing: .08em;\">SUPERVISED BY<\/p>\n<div style=\"display: flex; align-items: flex-start; gap: 1.2em; flex-wrap: wrap;\">\n<div style=\"flex-shrink: 0; text-align: center; min-width: 110px;\"><img decoding=\"async\" style=\"width: 100px; height: 100px; border-radius: 50%; object-fit: cover; object-position: top center; display: block; margin: 0 auto; border: 3px solid #e0e0e0;\" src=\"https:\/\/kojihifu.com\/hon\/wp-content\/uploads\/2022\/01\/photo-karibejun-400-3_re-300x300.jpg\" alt=\"Dr. Jun Karibe MD \u2014 Board-certified Plastic Surgeon, Director of Kojimachi Dermatology &amp; Plastic Surgery Clinic\" \/><\/p>\n<p style=\"margin: .6em 0 .1em; font-weight: bold; font-size: .95em; color: #222;\">Dr. Jun Karibe<\/p>\n<p style=\"margin: 0 0 .1em; font-size: .75em; color: #999;\">MD<\/p>\n<p style=\"margin: 0; font-size: .75em; color: #555; font-weight: bold;\">Director<\/p>\n<\/div>\n<div style=\"flex: 1; min-width: 200px;\">\n<div style=\"margin-bottom: .75em; background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Education &amp; Career<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Juntendo University School of Medicine<\/div>\n<div>Department of Plastic Surgery, University of Tokyo Hospital<\/div>\n<div>Assistant Professor, Plastic &amp; Cosmetic Surgery, Saitama Medical University<\/div>\n<div>Assistant Professor &amp; Chief Resident, Yamanashi University Hospital<\/div>\n<div>2019: Founded Kojimachi Dermatology &amp; Plastic Surgery Clinic (Ichigaya, Tokyo)<\/div>\n<div>2021: Founded BIOTOPE CLINIC Shirokanedai (Minato-ku, Tokyo)<\/div>\n<\/div>\n<\/div>\n<div style=\"margin-bottom: .75em; background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Certifications<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Board-certified Plastic Surgeon \u2014 Japan Society of Plastic and Reconstructive Surgery<\/div>\n<div>Specialist \u2014 Japan Society of Anti-Aging Medicine<\/div>\n<div>Certified Industrial Physician \u2014 Japan Medical Association<\/div>\n<div>Allergan VST-certified Injector (Botox &amp; Hyaluronic Acid)<\/div>\n<\/div>\n<\/div>\n<div style=\"background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Awards<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Best Presentation Award \u2014 Dept. of Plastic Surgery, University of Tokyo (2016)<\/div>\n<div>Excellence Award \u2014 Japan Society of Plastic and Reconstructive Surgery (2018)<\/div>\n<div>Featured Presentation \u2014 ASPS Annual Scientific Meeting, USA (2018)<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"margin-top: 1em; padding-top: .75em; border-top: 1px solid #e8e8e8; display: flex; flex-wrap: wrap; align-items: center; gap: .5em;\"><a style=\"display: inline-block; background: #e1306c; color: #fff; padding: .4em .9em; border-radius: 4px; text-decoration: none; font-size: .8em; font-weight: bold;\" href=\"https:\/\/www.instagram.com\/dr.jun_\/\" target=\"_blank\" rel=\"noopener noreferrer\">Instagram<\/a><\/p>\n<div style=\"margin-top: 1em; padding-top: .75em; border-top: 1px dashed #d5d5d5; font-size: .78em; color: #555; line-height: 1.7;\">\n<p style=\"margin: 0 0 .3em; font-size: .72em; font-weight: bold; color: #888; letter-spacing: .08em;\">MEDICAL REVIEW<\/p>\n<div><strong>Jun Karibe, MD<\/strong> \u2014 Board-certified Plastic Surgeon \u2014 Japan Society of Plastic and Reconstructive Surgery<\/div>\n<div>Medical Director, BIOTOPE CLINIC<\/div>\n<div>Last medically reviewed: 2026-09-15<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"Discover exosome therapy in Tokyo for skin rejuvenation and anti-aging \u2014 how it works, realistic results versus PRP and HIFU, and what to expect. Learn more.","protected":false},"author":4,"featured_media":12212,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20,21],"tags":[955,70],"class_list":["post-12213","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cosmetic-treatments","category-skin-dermatology","tag-prp","tag-hifu"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts\/12213","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/comments?post=12213"}],"version-history":[{"count":1,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts\/12213\/revisions"}],"predecessor-version":[{"id":12483,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts\/12213\/revisions\/12483"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/media\/12212"}],"wp:attachment":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/media?parent=12213"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/categories?post=12213"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/tags?post=12213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}