{"id":974,"date":"2026-07-12T12:59:28","date_gmt":"2026-07-12T03:59:28","guid":{"rendered":"https:\/\/kojihifu.com\/english\/?p=974"},"modified":"2026-07-13T18:35:11","modified_gmt":"2026-07-13T09:35:11","slug":"regenerative-medicine-tokyo-stem-cell-exosome","status":"publish","type":"post","link":"https:\/\/kojihifu.com\/english\/regenerative-medicine-tokyo-stem-cell-exosome\/","title":{"rendered":"Stem Cell vs Exosome vs Supernatant Tokyo"},"content":{"rendered":"<p><script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"Is regenerative medicine regulated in Japan?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Yes, but the level of regulation varies by modality. Cell-based therapies using living stem cells are regulated under Japan's Act on the Safety of Regenerative Medicine, which requires clinic protocol registration. Exosome products and conditioned medium are currently offered under free medical practice (\u81ea\u7531\u8a3a\u7642) and are not yet classified as pharmaceutical drugs in Japan. When considering treatment, it is reasonable to ask the clinic about their protocol registration status and the source and quality assurance of any products used.\"}}, {\"@type\": \"Question\", \"name\": \"How many sessions of exosome or supernatant therapy are typically needed?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Most published protocols and clinical guidance suggest an initial course of three to four sessions spaced three to four weeks apart, followed by maintenance sessions every three to six months. However, individual recommendations will vary based on skin condition, age, and treatment goals. A physician assessment is required to determine an appropriate protocol for your specific situation.\"}}, {\"@type\": \"Question\", \"name\": \"Can I combine regenerative treatments with Botox or filler on the same visit?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"In many cases, yes \u2014 but the sequencing and suitability depend on individual factors including the specific products used and the areas being treated. Some physicians prefer to separate sessions to allow for accurate assessment of each treatment's contribution to the result. This is a question well suited to the consultation appointment, where your overall treatment plan can be designed holistically.\"}}, {\"@type\": \"Question\", \"name\": \"Are results from regenerative medicine permanent?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"No regenerative medicine treatment produces permanent results in the traditional sense, as all skin tissues continue to age over time. However, improvements in collagen quality, skin texture, and hydration achieved through regenerative treatments can persist for several months to over a year, particularly with appropriate maintenance. The durability of results depends on the treatment modality, the number of sessions received, and ongoing skincare and sun protection practices.\"}}, {\"@type\": \"Question\", \"name\": \"Is it safe to receive regenerative treatment while visiting Tokyo as a short-term tourist?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"It is possible to receive lower-invasiveness treatments such as conditioned medium or exosome application during a short visit, particularly when combined with a microneedling or laser session. However, cell-based stem cell procedures \u2014 which require pre-operative assessment and may involve a harvest procedure \u2014 are generally not suitable for very short stays. Patients planning medical tourism for regenerative treatments are encouraged to factor in at least a follow-up window and to share their medical history with the treating physician in advance of arrival.\"}}]}<\/script><\/p>\n<h2>Regenerative Medicine in Tokyo: Stem Cell Therapy, Exosome Therapy, and Supernatant \u2014 What Is the Difference?<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Regenerative medicine Tokyo: stem cell vs exosome  \u2014 Regenerative Medicine in Tokyo: Stem Cell Therapy, Exosome T\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/07\/pexels_11532475_1783725535.webp\" alt=\"Regenerative medicine Tokyo: stem cell vs exosome  \u2014 Regenerative Medicine in Tokyo: Stem Cell Therapy, Exosome T\" \/><figcaption style=\"font-size: 0.8em; color: #888; text-align: right; margin-top: 4px;\">Photo: Pexels \/ Satheesh Sankaran<\/figcaption><\/figure>\n<p>If you have been researching skin rejuvenation or anti-ageing treatments in Tokyo, you may have encountered terms such as &#8220;stem cell therapy,&#8221; &#8220;exosome therapy,&#8221; and &#8220;stem cell supernatant&#8221; \u2014 sometimes used interchangeably, yet describing quite different approaches. Understanding the distinctions between these regenerative options is important before committing to any course of treatment.<\/p>\n<p>This article explains what each approach involves, how they compare in terms of mechanism, evidence, cost, downtime, and candidacy, so you can have a more informed conversation with a qualified physician.<\/p>\n<ul>\n<li>What stem cell therapy, exosome therapy, and supernatant (conditioned medium) each mean in plain language<\/li>\n<li>How these three regenerative approaches work at a biological level<\/li>\n<li>How they compare on evidence, safety profile, cost in Tokyo, and downtime<\/li>\n<li>Who is likely to benefit from regenerative medicine \u2014 and who should proceed with caution<\/li>\n<li>Frequently asked questions for international patients considering treatment in Japan<\/li>\n<\/ul>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>What Is Regenerative Medicine? An Overview of the Three Approaches<\/h2>\n<p>Regenerative medicine refers to treatments designed to stimulate the body&#8217;s own repair mechanisms \u2014 promoting collagen synthesis, improving tissue quality, and supporting cellular renewal. In an aesthetic context, these treatments are most commonly sought for skin rejuvenation, scar improvement, hair restoration, and anti-ageing.<\/p>\n<p>Three terms come up most frequently in Tokyo clinics: stem cell therapy, exosome therapy, and stem cell conditioned medium (also called supernatant or conditioned serum). Although all three are positioned under the regenerative medicine umbrella, they are biologically and regulatory distinct.<\/p>\n<h3>Stem Cell Therapy<\/h3>\n<p>Stem cells are undifferentiated cells with the capacity to develop into specialised cell types and to self-renew. In an aesthetic medicine context, the term most commonly refers to adipose-derived stem cells (ADSCs) \u2014 cells extracted from a patient&#8217;s own fat tissue, processed, and then re-administered, often as part of a fat grafting procedure or as an injectable preparation.<\/p>\n<p>Because stem cells are living cells, their handling, processing, and administration are subject to Japan&#8217;s Act on the Safety of Regenerative Medicine (\u518d\u751f\u533b\u7642\u5b89\u5168\u6027\u78ba\u4fdd\u6cd5), which requires clinics to register their protocols with the government before offering such treatments. This regulatory layer is an important quality signal when evaluating providers in Japan.<\/p>\n<h3>Exosome Therapy<\/h3>\n<p>Exosomes are nano-scale extracellular vesicles \u2014 tiny membrane-bound packages \u2014 naturally secreted by cells, including stem cells. They carry proteins, lipids, and genetic material (such as microRNA) that act as biological messengers, influencing neighbouring cells to behave in particular ways: reducing inflammation, stimulating collagen production, or signalling tissue repair.<\/p>\n<p>Because exosomes are not living cells, they do not carry the same replication risks associated with cell-based therapies. They are typically derived from donated human stem cells (often from umbilical cord or placenta sources) and supplied as a freeze-dried or liquid formulation. In Japan, exosome products occupy a regulatory grey area \u2014 they are not yet classified as pharmaceuticals and are offered under free medical practice,meaning the regulatory burden differs from that of cell-based therapies.<\/p>\n<h3>Stem Cell Conditioned Medium (Supernatant)<\/h3>\n<p>Stem cell conditioned medium \u2014 sometimes marketed as &#8220;stem cell supernatant&#8221; or &#8220;stem cell culture supernatant&#8221; \u2014 is the liquid in which stem cells have been cultured. After the cells are removed, the remaining fluid contains the growth factors, cytokines, and signalling molecules that those cells secreted during culture.<\/p>\n<p>This approach does not involve administering any cells at all. The conditioned medium is rich in epidermal growth factor (EGF), fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), and other mediators. It can be applied topically (for example, after microneedling) or injected. It is the most accessible and most leniently regulated of the three approaches in Japan, and consequently the most widely offered.<\/p>\n<h2>How Each Approach Works: The Biological Mechanism<\/h2>\n<p>All three modalities ultimately aim to deliver regenerative signals to the skin \u2014 but at different levels of biological complexity and potency.<\/p>\n<p>Stem cells, when successfully engrafted, can theoretically secrete regenerative factors in a sustained manner over time. However, the survival and engraftment of transplanted stem cells in aesthetic applications remains variable, and much of the observed clinical benefit may itself come from paracrine signalling \u2014 meaning the factors those cells secrete \u2014 rather than the cells directly differentiating into new tissue.<\/p>\n<p>Exosomes represent a more targeted delivery of those paracrine signals. Because they are membrane-enclosed, their cargo (proteins and RNA) is protected from rapid enzymatic degradation. Studies suggest exosomes from mesenchymal stem cells can upregulate collagen type I synthesis and reduce matrix metalloproteinase (MMP) activity \u2014 key mechanisms in skin rejuvenation. A 2021 review published in <em>Stem Cell Research &amp; Therapy<\/em> noted that exosome-based treatments demonstrated measurable improvements in skin hydration and elasticity in clinical series, though the authors stressed the need for larger randomised trials.<\/p>\n<p>Conditioned medium offers a more dilute but still meaningful growth factor payload. It is well suited to combination with physical delivery methods \u2014 such as microneedling or fractional laser \u2014 that temporarily increase skin permeability and allow topical or intradermal uptake of active molecules.<\/p>\n<h2>Comparing Stem Cell, Exosome, and Supernatant Treatments<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Regenerative medicine Tokyo: stem cell vs exosome  \u2014 Comparing Stem Cell, Exosome, and Supernatant Treatments\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/07\/pexels_11532478_1783725538.webp\" alt=\"Regenerative medicine Tokyo: stem cell vs exosome  \u2014 Comparing Stem Cell, Exosome, and Supernatant Treatments\" \/><figcaption style=\"font-size: 0.8em; color: #888; text-align: right; margin-top: 4px;\">Photo: Pexels \/ Satheesh Sankaran<\/figcaption><\/figure>\n<p>The table below summarises the key differences across the three regenerative approaches to help you ask the right questions during a consultation.<\/p>\n<table style=\"border-collapse: collapse; width: 100%; margin: 20px 0; font-size: 0.95em; border: 1px solid #ccc;\">\n<thead>\n<tr>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Feature<\/th>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Stem Cell Therapy<\/th>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Exosome Therapy<\/th>\n<th style=\"border: 1px solid #ccc; padding: 10px 12px; background: #f1faf3; text-align: left; font-weight: bold;\">Supernatant \/ Conditioned Medium<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\"><strong>What is administered<\/strong><\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Living stem cells (typically autologous)<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Nano-vesicles derived from stem cells<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Growth factor-rich cell-free fluid<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\"><strong>Regulatory status in Japan<\/strong><\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Regulated under the Regenerative Medicine Safety Act; clinic registration required<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Offered under free medical practice; not yet classified as pharmaceutical<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Offered under free medical practice; lightest regulatory burden<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\"><strong>Source<\/strong><\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Usually autologous (patient&#8217;s own fat or blood)<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Usually allogeneic (donor-derived, e.g., umbilical cord)<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Allogeneic cell culture medium<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\"><strong>Invasiveness<\/strong><\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">High \u2014 fat harvest or blood draw required<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Low to moderate \u2014 injection or topical application<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Low \u2014 topical or minimally invasive injection<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\"><strong>Downtime<\/strong><\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Several days to weeks (harvest site recovery)<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Minimal \u2014 redness 24\u201348 hours if injected<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Minimal \u2014 typically none to 1\u20132 days<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\"><strong>Evidence base<\/strong><\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Moderate; stronger for reconstructive than cosmetic use<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Emerging; promising early clinical data<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Moderate for growth factor benefits; delivery method matters<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\"><strong>Typical Tokyo cost range<\/strong><\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">From approximately \u00a5300,000\u2013\u00a51,000,000+ per session<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">From approximately \u00a550,000\u2013\u00a5300,000 per session<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">From approximately \u00a520,000\u2013\u00a580,000 per session or as add-on<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\"><strong>Combination potential<\/strong><\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Often combined with fat grafting<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Often combined with microneedling, laser, or injection<\/td>\n<td style=\"border: 1px solid #ccc; padding: 10px 12px; vertical-align: top;\">Commonly combined with Dermapen or fractional laser<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Expected Results and Evidence<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Regenerative medicine Tokyo: stem cell vs exosome  \u2014 Expected Results and Evidence\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/07\/pexels_9629706_1783725539.webp\" alt=\"Regenerative medicine Tokyo: stem cell vs exosome  \u2014 Expected Results and Evidence\" \/><figcaption style=\"font-size: 0.8em; color: #888; text-align: right; margin-top: 4px;\">Photo: Pexels \/ Ivan S<\/figcaption><\/figure>\n<p>It is important to approach regenerative medicine with realistic expectations. None of these treatments produce overnight transformation, and results vary considerably depending on individual biology, skin condition, age, and the delivery method used.<\/p>\n<p>Clinical reports indicate that patients undergoing exosome treatment in combination with microneedling tend to report improved skin texture, luminosity, and hydration within four to eight weeks of treatment.<\/p>\n<p>A clinical series published in the <em>Journal of Cosmetic Dermatology<\/em> (2022) found that participants receiving exosome-augmented microneedling showed a statistically significant improvement in skin roughness and melanin index compared to microneedling alone, though the study sample size was modest.<\/p>\n<p>Supernatant-based treatments, when delivered via a physical channel such as fractional laser or Dermapen, may support wound healing, reduce post-procedural inflammation, and enhance collagen stimulation. They are frequently offered as an add-on rather than a standalone protocol.<\/p>\n<p>Stem cell treatments, where performed under appropriate regulatory compliance, are associated with the most sustained results \u2014 partly because the cells may continue secreting growth factors over time.<\/p>\n<p>However, results in cosmetic applications are variable, and this modality requires significantly greater investment in terms of cost, time, and procedural complexity.<\/p>\n<blockquote style=\"border-left: 4px solid #5a8a5a; padding: .75em 1.1em; margin: 1.8em 0; background: #f7fbf7; border-radius: 0 6px 6px 0; font-size: .93em;\">\n<p style=\"margin: 0 0 .45em; font-weight: bold; color: #3a6e3a;\">Dr. Karibe&#8217;s Note<\/p>\n<p style=\"margin: 0; color: #333; line-height: 1.7;\">Many of our international patients arrive having already researched regenerative treatments online and are understandably excited by the terminology.<\/p>\n<p style=\"margin: 0; color: #333; line-height: 1.7;\">A common question I receive is: &#8220;Which is stronger \u2014 exosomes or stem cells?&#8221; My honest answer is that potency alone is not the right framework.<\/p>\n<p style=\"margin: 0; color: #333; line-height: 1.7;\">The correct question is which approach is appropriately matched to your skin concerns, health status, and expectations.<\/p>\n<p style=\"margin: 0; color: #333; line-height: 1.7;\">A thorough consultation, including a review of your medical history and skin assessment, is always the starting point before any recommendation is made.<\/p>\n<\/blockquote>\n<h2>What People Often Get Wrong About Regenerative Medicine<\/h2>\n<h3>Misconception 1: &#8220;Stem cell&#8221; labelling always means living cells are used<\/h3>\n<p>Many products and treatments marketed in Japan and globally as &#8220;stem cell&#8221; are in fact conditioned medium or growth factor extracts \u2014 no living stem cells are present.<\/p>\n<p>This is not necessarily a deficiency, since the growth factors themselves have biological value, but the terminology can be misleading. Patients should ask their physician directly: &#8220;Will living cells be administered, or is this a conditioned medium or exosome product?&#8221;<\/p>\n<h3>Misconception 2: More regenerative treatments equal faster or better results<\/h3>\n<p>There is a tendency \u2014 particularly in the medical tourism context \u2014 to assume that stacking multiple regenerative sessions in a short period accelerates outcomes.<\/p>\n<p>In practice, skin remodelling is a biological process governed by collagen synthesis cycles, which take weeks to months. Over-treating within a short window does not speed this up and may in some cases cause unnecessary inflammation.<\/p>\n<p>A well-spaced, evidence-guided protocol is generally more effective than a high-volume short-stay approach.<\/p>\n<h2>Cost in Tokyo<\/h2>\n<figure style=\"margin: 1.5em 0;\"><img decoding=\"async\" style=\"width: 100%; max-width: 100%; height: auto; border-radius: 8px;\" title=\"Regenerative medicine Tokyo: stem cell vs exosome  \u2014 Cost in Tokyo\" src=\"https:\/\/kojihifu.com\/english\/wp-content\/uploads\/2026\/07\/pexels_4031369_1783725540.webp\" alt=\"Regenerative medicine Tokyo: stem cell vs exosome  \u2014 Cost in Tokyo\" \/><figcaption style=\"font-size: 0.8em; color: #888; text-align: right; margin-top: 4px;\">Photo: Pexels \/ Edward Jenner<\/figcaption><\/figure>\n<p>Regenerative medicine treatments in Tokyo are offered exclusively as private (self-pay) procedures.<\/p>\n<p>There is no health insurance coverage for any of the three modalities described in this article.<\/p>\n<p>As a general guide for the Tokyo market, stem cell therapy \u2014 particularly autologous ADSC procedures \u2014 can range from approximately \u00a5100,000 to over \u00a51,000,000 per session depending on protocol complexity.<\/p>\n<p>Exosome therapy sessions typically fall in the \u00a550,000 to \u00a5300,000 range depending on the exosome product used, the concentration, and whether it is combined with an energy-based device.<\/p>\n<p>Conditioned medium \/ supernatant treatments are often offered as add-ons to existing procedures \u2014 for example, applied post-Dermapen or post-fractional laser \u2014 and may add \u00a520,000 to \u00a580,000 to the base procedure cost.<\/p>\n<p>At BIOTOPE CLINIC or Kojimachi Dermatology &amp; Plastic Surgery Clinic, Dermapen is available from \u00a59,800, and CO2 fractional laser from \u00a511,000, both of which are device options commonly combined with regenerative adjuncts. These treatments are available at our Ichigaya clinic \u2014 feel free to ask about combination protocols during a consultation.<\/p>\n<p>For an accurate quote, we recommend booking a consultation.<\/p>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>Who Is a Good Candidate \u2014 and Who Should Proceed with Caution<\/h2>\n<h3>Suitable candidates<\/h3>\n<ul>\n<li>Adults in good general health who are seeking non-surgical skin rejuvenation and are willing to undergo a course of treatment rather than expecting a single-session result<\/li>\n<li>Patients with early to moderate signs of skin ageing, uneven texture, dullness, or mild laxity<\/li>\n<li>Those who have already optimised the basics \u2014 sun protection, skincare routine, nutrition \u2014 and are looking for an adjunctive biological boost<\/li>\n<li>Patients interested in post-procedure recovery support following laser or microneedling treatments<\/li>\n<\/ul>\n<h3>Those who should proceed with caution or seek medical clearance first<\/h3>\n<ul>\n<li>Individuals with active autoimmune conditions, immunosuppression, or a personal or family history of malignancy \u2014 a physician review is essential before any regenerative therapy<\/li>\n<li>Pregnant or breastfeeding individuals<\/li>\n<li>Those with active skin infections, open wounds, or inflammatory skin conditions in the treatment area<\/li>\n<li>Patients expecting dramatic results from a single session \u2014 a realistic discussion of goals must precede treatment<\/li>\n<\/ul>\n<p>In our clinical experience at BIOTOPE CLINIC or \u00a0Kojimachi Dermatology &amp; Plastic Surgery Clinic, international patients seeking regenerative treatments often benefit most from a staged approach: beginning with a thorough skin assessment and, where relevant, combining regenerative adjuncts with evidence-based energy devices for a synergistic outcome.<\/p>\n<h2>Frequently Asked Questions<\/h2>\n<dl class=\"kj-faq\">\n<dt>Q. Is regenerative medicine regulated in Japan?<\/dt>\n<dd>Yes, but the level of regulation varies by modality. Cell-based therapies using living stem cells are regulated under Japan&#8217;s Act on the Safety of Regenerative Medicine, which requires clinic protocol registration. Exosome products and conditioned medium are currently offered under free medical practice (\u81ea\u7531\u8a3a\u7642) and are not yet classified as pharmaceutical drugs in Japan. When considering treatment, it is reasonable to ask the clinic about their protocol registration status and the source and quality assurance of any products used.<\/dd>\n<dt>Q. How many sessions of exosome or supernatant therapy are typically needed?<\/dt>\n<dd>Most published protocols and clinical guidance suggest an initial course of three to four sessions spaced three to four weeks apart, followed by maintenance sessions every three to six months. However, individual recommendations will vary based on skin condition, age, and treatment goals. A physician assessment is required to determine an appropriate protocol for your specific situation.<\/dd>\n<dt>Q. Can I combine regenerative treatments with Botox or filler on the same visit?<\/dt>\n<dd>In many cases, yes \u2014 but the sequencing and suitability depend on individual factors including the specific products used and the areas being treated. Some physicians prefer to separate sessions to allow for accurate assessment of each treatment&#8217;s contribution to the result. This is a question well suited to the consultation appointment, where your overall treatment plan can be designed holistically.<\/dd>\n<dt>Q. Are results from regenerative medicine permanent?<\/dt>\n<dd>No regenerative medicine treatment produces permanent results in the traditional sense, as all skin tissues continue to age over time. However, improvements in collagen quality, skin texture, and hydration achieved through regenerative treatments can persist for several months to over a year, particularly with appropriate maintenance. The durability of results depends on the treatment modality, the number of sessions received, and ongoing skincare and sun protection practices.<\/dd>\n<dt>Q. Is it safe to receive regenerative treatment while visiting Tokyo as a short-term tourist?<\/dt>\n<dd>It is possible to receive lower-invasiveness treatments such as conditioned medium or exosome application during a short visit, particularly when combined with a microneedling or laser session.<\/dd>\n<dd>However, cell-based stem cell procedures \u2014 which require pre-operative assessment and may involve a harvest procedure \u2014 are generally not suitable for very short stays. Patients planning medical tourism for regenerative treatments are encouraged to factor in at least a follow-up window and to share their medical history with the treating physician in advance of arrival.<\/dd>\n<\/dl>\n<div class=\"kjmc-en-booking-inline\" style=\"background: #f7fbf7; border: 1px solid #d5e6d8; border-radius: 10px; padding: 16px 20px; margin: 26px 0; text-align: center;\">\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 0.95em; line-height: 1.65;\"><strong>Have a question about this treatment?<\/strong><br \/>\nMessage us on LINE or WhatsApp \u2014 our English-speaking team usually replies the same day.<\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; gap: 8px; background: #06C755; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><br \/>\n<a style=\"display: inline-flex; align-items: center; gap: 8px; background: #25D366; color: #fff; padding: 10px 20px; border-radius: 8px; text-decoration: none; font-weight: bold; font-size: 0.92em; margin: 4px 6px; white-space: nowrap; vertical-align: middle;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>Summary<\/h2>\n<p>Regenerative medicine in Tokyo encompasses three distinct but related approaches \u2014 stem cell therapy, exosome therapy, and stem cell conditioned medium (supernatant) \u2014 each differing in biological mechanism, regulatory status, invasiveness, cost, and evidence base. Stem cell therapy offers the most biologically complex intervention but also the highest cost and procedural burden.<\/p>\n<p>Exosome therapy represents a promising middle ground, delivering key regenerative signals without living cells. Conditioned medium is the most accessible and is frequently used as a synergistic adjunct to laser or microneedling treatments.<\/p>\n<p>Selecting the appropriate approach requires an individualised assessment by a qualified physician who can match the treatment to your specific skin concerns, health history, and treatment goals.<\/p>\n<p>As with all cosmetic medicine, outcomes are not guaranteed \u2014 but evidence suggests that well-selected patients, treated according to appropriate protocols, can achieve meaningful improvements in skin quality and vitality.<\/p>\n<p style=\"padding-left: 40px;\">If you have questions about regenerative medicine in Tokyo \u2014 including how stem cell, exosome, and supernatant options compare \u2014 our team at BIOTOPE CLINIC or Kojimachi Dermatology &amp; Plastic Surgery Clinic in Tokyo would be happy to help. We offer consultations in English.<\/p>\n<div class=\"kjmc-en-booking-box\" style=\"background: linear-gradient(135deg,#f1faf3 0%,#e6f3ea 100%); border-radius: 14px; padding: 32px 24px; margin: 36px 0 24px; border: 1px solid #c5dccd; text-align: center;\">\n<h3 style=\"margin: 0 0 8px; color: #3a6e3a; border: none; padding: 0; font-size: 1.3em;\">24\/7 Consultation &amp; Booking<\/h3>\n<div style=\"width: 48px; height: 2px; background: #3a6e3a; margin: 0 auto 22px;\"><\/div>\n<p style=\"margin: 0 0 12px; color: #1a3a1f; font-size: 1.1em; font-weight: bold;\">Book a Consultation or Treatment<\/p>\n<p style=\"margin: 0 0 24px; color: #2c4a35; line-height: 1.75;\">Our English-speaking team responds via LINE or WhatsApp \u2014 usually the same day.<\/p>\n<p style=\"margin: 0 0 10px; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; justify-content: center; gap: 10px; background: #06C755; color: #fff; padding: 14px 32px; border-radius: 10px; text-decoration: none; font-weight: bold; font-size: 1.02em; box-shadow: 0 2px 8px rgba(6,199,85,0.25); min-width: 240px; white-space: nowrap;\" href=\"https:\/\/line.me\/R\/ti\/p\/@710uitns?ts=05311801&amp;oat_content=url#~\" target=\"_blank\" rel=\"noopener noreferrer\">Book via LINE<\/a><\/p>\n<p style=\"margin: 0; line-height: 1;\"><a style=\"display: inline-flex; align-items: center; justify-content: center; gap: 10px; background: #25D366; color: #fff; padding: 14px 32px; border-radius: 10px; text-decoration: none; font-weight: bold; font-size: 1.02em; box-shadow: 0 2px 8px rgba(37,211,102,0.25); min-width: 240px; white-space: nowrap;\" href=\"https:\/\/whatsapp.com\/channel\/0029VbCA1v85K3zY4MLX2a1h\" target=\"_blank\" rel=\"noopener noreferrer\">Message on WhatsApp<\/a><\/p>\n<\/div>\n<h2>References<\/h2>\n<ol>\n<li>Fang S, Xu C, Zhang Y, et al. Umbilical cord-derived mesenchymal stem cell-derived exosomal microRNAs suppress myofibroblast differentiation by inhibiting the TGF-beta\/SMAD2 pathway during wound healing. <em>Stem Cells Translational Medicine<\/em>. 2016.<\/li>\n<li>Guo SC, Tao SC, Yin WJ, et al. Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocytes. <em>Theranostics<\/em>. 2017.<\/li>\n<li>Kim YJ, Yoo SM, Park HH, et al. Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulates rejuvenation of human skin. <em>Biochemical and Biophysical Research Communications<\/em>. 2017.<\/li>\n<li>Rajendran RL, Gangadaran P, Bak SS, et al. Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice. <em>Scientific Reports<\/em>. 2017.<\/li>\n<li>Choi EW, Seo MK, Woo EY, Kim SH, Park EJ, Kim S. Exosomes from human adipose-derived stem cells promote proliferation and migration of skin fibroblasts. <em>Experimental Dermatology<\/em>. 2018.<\/li>\n<\/ol>\n<h2>Related Articles<\/h2>\n<p>You may also find these articles useful.<\/p>\n<ul>\n<li><a href=\"https:\/\/kojihifu.com\/english\/non-surgical-facelift-tokyo-foreigners-guide\/\" target=\"_blank\" rel=\"noopener\">Non-Surgical Facelift Tokyo for Foreigners: Full Guide<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/hifu-tokyo-non-surgical-skin-tightening\/\" target=\"_blank\" rel=\"noopener\">HIFU in Tokyo: Non-Surgical Skin Tightening Explained<\/a><\/li>\n<li><a href=\"https:\/\/kojihifu.com\/english\/tokyo-skin-tightening\/\" target=\"_blank\" rel=\"noopener\">Popular Non-Surgical Skin Tightening Treatments in Tokyo for International Patients<\/a><\/li>\n<\/ul>\n<div style=\"margin: 2.5em 0 1em; padding: 1.5em; border: 1px solid #d5d5d5; border-radius: 10px; background: #fafafa; font-size: .9em;\">\n<p style=\"font-size: .72em; font-weight: bold; color: #888; margin: 0 0 1.2em; letter-spacing: .08em;\">SUPERVISED BY<\/p>\n<div style=\"display: flex; align-items: flex-start; gap: 1.2em; flex-wrap: wrap;\">\n<div style=\"flex-shrink: 0; text-align: center; min-width: 110px;\"><img decoding=\"async\" style=\"width: 100px; height: 100px; border-radius: 50%; object-fit: cover; object-position: top center; display: block; margin: 0 auto; border: 3px solid #e0e0e0;\" src=\"https:\/\/kojihifu.com\/hon\/wp-content\/uploads\/2022\/01\/photo-karibejun-400-3_re-300x300.jpg\" alt=\"Dr. Jun Karibe MD \u2014 Board-certified Plastic Surgeon, Director of Kojimachi Dermatology &amp; Plastic Surgery Clinic\" \/><\/p>\n<p style=\"margin: .6em 0 .1em; font-weight: bold; font-size: .95em; color: #222;\">Dr. Jun Karibe<\/p>\n<p style=\"margin: 0 0 .1em; font-size: .75em; color: #999;\">MD<\/p>\n<p style=\"margin: 0; font-size: .75em; color: #555; font-weight: bold;\">Director<\/p>\n<\/div>\n<div style=\"flex: 1; min-width: 200px;\">\n<div style=\"margin-bottom: .75em; background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Education &amp; Career<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Juntendo University School of Medicine<\/div>\n<div>Department of Plastic Surgery, University of Tokyo Hospital<\/div>\n<div>Assistant Professor, Plastic &amp; Cosmetic Surgery, Saitama Medical University<\/div>\n<div>Assistant Professor &amp; Chief Resident, Yamanashi University Hospital<\/div>\n<div>2019: Founded Kojimachi Dermatology &amp; Plastic Surgery Clinic (Ichigaya, Tokyo)<\/div>\n<div>2021: Founded BIOTOPE CLINIC Shirokanedai (Minato-ku, Tokyo)<\/div>\n<\/div>\n<\/div>\n<div style=\"margin-bottom: .75em; background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Certifications<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Board-certified Plastic Surgeon \u2014 Japan Society of Plastic and Reconstructive Surgery<\/div>\n<div>Specialist \u2014 Japan Society of Anti-Aging Medicine<\/div>\n<div>Certified Industrial Physician \u2014 Japan Medical Association<\/div>\n<div>Allergan VST-certified Injector (Botox &amp; Hyaluronic Acid)<\/div>\n<\/div>\n<\/div>\n<div style=\"background: #fff; border: 1px solid #ebebeb; border-radius: 6px; padding: .7em 1em;\">\n<p style=\"margin: 0 0 .35em; font-size: .78em; font-weight: bold; color: #666; border-bottom: 1px solid #f2f2f2; padding-bottom: .3em;\">Awards<\/p>\n<div style=\"font-size: .82em; color: #444; line-height: 1.75;\">\n<div>Best Presentation Award \u2014 Dept. of Plastic Surgery, University of Tokyo (2016)<\/div>\n<div>Excellence Award \u2014 Japan Society of Plastic and Reconstructive Surgery (2018)<\/div>\n<div>Featured Presentation \u2014 ASPS Annual Scientific Meeting, USA (2018)<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"margin-top: 1em; padding-top: .75em; border-top: 1px solid #e8e8e8; display: flex; flex-wrap: wrap; align-items: center; gap: .5em;\"><a style=\"display: inline-block; background: #e1306c; color: #fff; padding: .4em .9em; border-radius: 4px; text-decoration: none; font-size: .8em; font-weight: bold;\" href=\"https:\/\/www.instagram.com\/dr.jun_\/\" target=\"_blank\" rel=\"noopener noreferrer\">Instagram<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"Compare stem cell, exosome, and supernatant regenerative medicine in Tokyo. Understand mechanisms, evidence, cost, and downtime to choose the right treatment for you.","protected":false},"author":4,"featured_media":1048,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20,21],"tags":[276,277,278,279,246,108,56],"class_list":["post-974","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cosmetic-treatments","category-skin-dermatology","tag-stem-cell-therapy","tag-exosome-therapy","tag-supernatant-treatment","tag-japan-clinic","tag-regenerative-medicine","tag-skin-rejuvenation","tag-anti-aging-tokyo"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts\/974","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/comments?post=974"}],"version-history":[{"count":2,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts\/974\/revisions"}],"predecessor-version":[{"id":1051,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/posts\/974\/revisions\/1051"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/media\/1048"}],"wp:attachment":[{"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/media?parent=974"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/categories?post=974"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kojihifu.com\/english\/wp-json\/wp\/v2\/tags?post=974"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}